关键词: 脑出血; 心肌缺血; 心电描记术; 肌酸激酶; 肌酸激酶; MB; L-乳酸脱氢酶; 羟丁酸脱氢酶

Abstract: Objective To observe the change of P-wave dispersion (Pdisp) and myocardial enzymes in thepatients with acute intracerebral hemorrhage (AICH), and to explore the characteristics ofmyocardial damage.Methods Two-hundred and twenty-seven AICH patients were enrolled. The electrocardiogram wasexamined within 24-hour (24h) and on the seventh day (7d) after admission. The maximum P-wavetiming (Pmax) and minimum P-wave timing (Pmin) were measured, and the Pdisp was calculated. Thepatients were divided into three groups according to the Glasgow scale, including the mild (13-15scores), moderate (9-12 scores) and severe group (3-8 scores). The blood myocardial enzymes,including lactate dehydrogenase (LDH), alpha-hydroxybutyrate dehydrogenase (α-HBDH), creatinekinase (CK), and MB isoenzyme of creatine kinase (CK-MB) were examined within 24h andcompared among the three groups.Results The Pmin within 24h had no difference with that on the 7d (P =0.710). However, the AICHpatients showed significantly more prolonged Pmax (P =0.002) and Pdisp (P =0.006) within 24h thanthat on the 7d. The positive number of Pmax more than 110ms was significantly higher within 24h(19.8%) than that on the 7d (5.7%, P <0.01). Similarly, the positive number of Pdisp more than40ms was also higher within 24h (67.4%) than that on the 7d (58.1%, P =0.041). It showed markeddifferences in myocardial enzymes among the three groups (P <0.01). CK, CK-MB, LDH andα-HBDH in severe group were obviously higher than that of moderate and mild groups (P <0.01).The cardiac enzymes in moderate group were also higher than that of mild group (P <0.01).Conclusion The myocardial damage existed in AICH patients with different degrees; it was closelyrelated to the severe degree of the AICH.

Key words: Cerebral hemorrhage; Myocardial ischemia; Electrocardiography; Creatine kinase; Creatine kinase; MB form; L-lactate dehydrogenase; L-lactatedehydrogenase