Abstract:

Objective To investigate the relationship between the levels of serum homocysteine (Hcy), fibrinogen (FIB), cystatin-C (Cys-C) and NIHSS at admission in patients with acute cerebral infarction. Methods Patients with acute cerebral infarction admitted to Department of Neurology, Kangji Xintu Hospital from January 2014 to November 2018 were retrospectively selected. According to NIHSS score at admission, all the patients were divided into mild (NIHSS<7 points), moderate (7 points≤NIHSS<15 points) and severe stroke (NIHSS≥15 points) groups. The differences of serum Hcy, FIB and Cys-c levels among the three groups were compared, and the relationship between serum Hcy, FIB and Cys-c levels and NIHSS score were further evaluated by Spearman correlation analysis. Results A total of 4468 eligible patients were included, with the median age of 65.00 (IQR 65.00- 72.00) years and 2765 males (61.88%). Of all, 3943 (88.25%) cases were in mild stroke group, 441 (9.87%) in moderate stroke group and 84 (1.88%) in severe stroke group, The levels of Hcy (P <0.001), FIB (P <0.001) and Cys-C (P =0.035) in three groups were significantly different and the levels in mild stroke group were lower than that in moderate and severe stroke groups. The correlation analysis showed that Hcy (r =0.770, P <0.001), FIB (r =0.440, P =0.003), Cys-C (r =0.580, P <0.001) were positively correlated with NIHSS score at admission.

Conclusions Serum Hcy, FIB and Cys-C levels were positively correlated with NIHSS score at admission in patients with acute cerebral infarction.

Key words: Acute ischemic stroke; National Institute of Health stroke scale; Homocysteine;Fibrinogen; Cystatin-C

摘要：

目的 探讨入院时血清同型半胱氨酸（homocysteine，Hcy）、纤维蛋白原（fibrinogen，FIB）和胱抑素C （cystatin-C，Cys-C）水平与急性脑梗死患者NIHSS评分的关系。 方法 回顾性纳入2014年1月-2018年11月于任丘康济新图医院神经内科住院的急性脑梗死患者，依 据入院时NIHSS评分分为轻型组（NIHSS评分＜7分）、中型组（7分≤NIHSS评分＜15分）、重型组（NIHSS 评分≥15分）。比较三组间血清Hcy、FI B、Cys-C水平差异，进一步用Spearman相关分析评估血清Hcy、 FI B、Cys-C水平与NIHSS评分的关系。 结果 共纳入4468例患者，中位年龄65.00（65.00～72.00）岁，男性2765例（61.88%）。轻型组3943 例（88.25%），中型组441例（9.87%），重型组84例（1.88%）。三组间血清Hcy（P＜0.001）、FI B（P ＜0.001）、Cys-C（P =0.035）水平比较，整体差异有统计学意义；进一步两两比较发现，轻型组血清 Hcy、FI B和Cys-C水平均低于中型组和重型组。Spearman相关分析发现，血清Hcy（r =0.770，P＜0.001）、 FI B（r =0.440，P =0.003）、Cys-C（r =0.580，P＜0.001）水平与急性脑梗死患者NIHSS评分呈正相关。 结论 急性脑梗死患者血清Hcy、FI B、Cys-C水平与NIHSS评分呈正相关。

关键词: 急性缺血性卒中; 美国国立卫生研究院卒中量表; 同型半胱氨酸; 纤维蛋白原; 胱抑素C