Chinese Journal of Stroke ›› 2020, Vol. 15 ›› Issue (04): 446-451.DOI: 10.3969/j.issn.1673-5765.2020.04.020
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Received:
2020-01-06
Online:
2020-04-20
Published:
2020-04-20
徐慈航,李敬伟,朱晓蕾
通讯作者:
朱晓蕾 zhuquelee@126.com
基金资助:
江苏省青年医学人才项目(QNRC2016024)
江苏省科协青年托举工程项目
XU Ci-Hang, LI Jing-Wei, ZHU Xiao-Lei. Advance in Hemorrhagic Transformation after Acute Ischemic Stroke[J]. Chinese Journal of Stroke, 2020, 15(04): 446-451.
徐慈航,李敬伟,朱晓蕾. 急性缺血性卒中出血转化的研究进展[J]. 中国卒中杂志, 2020, 15(04): 446-451.
[1] YAGHI S,WILLEY J Z,CUCCHIARA B,etal. Treatment and outcome of hemorrhagictransformation after intravenous alteplase in acuteischemic stroke:a scientific statement for healthcareprofessionals from the American Heart Association/American Stroke Association[J/OL]. Stroke,2017,48(12):e343-e361[2019-12-15]. https://doi.org/10.1161/STR.0000000000000152.[2] TSIRKA S E,GUALANDRIS A,AMARAL DG,et al. Excitotoxin-induced neuronal degenerationand seizure are mediated by tissue plasminogenactivator[J]. Nature,1995,377(6547):340-344.[3] LIU D,CHENG T,GUO H,et al. tPA neurovasculartoxicity is controlled by activated protein C[J]. NatMed,2004,10(12):1379-1383.[4] CUADRADO E,ORTEGA L,HERNÁNDEZGUILLAMONM,et al. Tissue plasminogenactivator(t-PA)promotes neutrophil degranulationand MMP-9 release[J]. J Leukoc Biol,2008,84(1):207-214.[5] LU G,HE Q,SHEN Y,et al. Potential biomarkersfor predicting hemorrhagic transformation ofischemic stroke[J]. Int J Neurosci,2018,128(1):79-89. [6] HARTMANN S,RIDLEY A J,LUTZ S. Thefunction of rho-associated kinases ROCK1 andROCK2 in the pathogenesis of cardiovasculardisease[J]. Front Pharmacol,2015,6(5):276.[7] JICKLING G C,LIU D,STAMOVA B,et al.Hemorrhagic transformation after ischemic stroke inanimals and humans[J]. J Cereb Blood Flow Metab,2014,34(2):185-199.[8] YAMAGUCHI T,AWANO H,MATSUDA H,etal. Edaravone with and without. 6 mg/kg alteplasewithin 4.5 hours after ischemic stroke:a prospectivecohort study(PROTECT 4.5)[J]. J StrokeCerebrovasc Dis,2017,26(4):756-765.[9] CAMPOS F,QIN T,CASTILLO J,et al. Fingolimodreduces hemorrhagic transforma tion associated withdelayed tissue plasminogen activator treatment in amouse thromboembolic model[J]. Stroke,2013,44(2):505-511.[10] ROGOVE A D,SIAO C,KEYT B,et al. Activationof microglia reveals a non-proteolytic cytokinefunction for tissue plasminogen activator in thecentral nervous system[J]. J Cell Sci,1999,112(22):4007-4016.[11] SHI Z S,DUCKWILER G R,JAHAN R,et al.Early blood‐brain barrier disruption after mechanicalthrombectomy in acute ischemic stroke[J]. JNeuroimaging,2018,28(3):283-288.[12] SHI Z S,LIEBESKIND D S,LOH Y,et al,Predictors of subarachnoid hemorrhage in acuteischemic stroke with endovascular therapy[J]. Stroke,2010,41(12):2775-2781.[13] SAVER J L,GOYAL M,VAN DER LUGT A,et al.Time to treatment with endovascular thrombectomyand outcomes from ischemic stroke:a metaanalysis[J]. JAMA,2016,316(12):1279-1288.[14] NOGUEIRA R G,JADHAV A P,HAUSSEN D C,et al. Thrombectomy 6 to 24 hours after stroke witha mismatch between deficit and infarct[J]. N Engl JMed,2018,378(1):11-21.[15] ALBERS G W,MARKS M P,KEMP S,et al.Thrombectomy for stroke at 6 to 16 hours withselection by perfusion imaging[J]. N Engl J Med,2018,378(8):708-718.[16] International Stroke Trial Collaborative Group. TheInternational Stroke Trial(IST):a randomisedtrial of aspirin,subcutaneous heparin,both,orneither among 19 435 patients with acute ischaemicstroke[J]. Lancet,1997,349(9065):1569-1581.[17] TSIVGOULIS G,KATSANOS A H,MAVRIDIS D,et al. Intravenous thrombolysis for ischemic strokepatients on dual antiplatelets[J]. Ann Neurol,2018,84(1):89-97.[18] DIEDLER J,AHMED N,SYKORA M,et al. Safetyof intravenous thrombolysis for acute ischemicstroke in patients receiving antiplatelet therapy atstroke onset[J]. Stroke,2010,41(2):288-294.[19] LUO S,ZHUANG M,ZENG W,et al. Intravenousthrombolysis for acute ischemic stroke in patientsreceiving antiplatelet therapy:a systematic reviewand meta-analysis of 19 studies[J/OL]. J Am HeartAssoc,2016,5(5):e003242[2019-12-15]. https://doi.org/10.1161/JAHA.116.003242.[20] SA?ÁK D,KULIHA M,HERZIG R,et al. Prioruse of antiplatelet therapy can be associated witha higher chance for early recanalization of theoccluded middle cerebral artery in acute strokepatients treated with intravenous thrombolysis[J].Eur Neurol,2012,67(1):52-56.[21] ZINKSTOK S M,ROOS Y B,ARTIS investigators.Early administration of aspirin in patients treatedwith alteplase for acute ischaemic stroke:arandomised controlled trial[J]. Lancet,2012,380(9843):731-737.[22] RESTART Collaboration. Effects of antiplatelettherapy after stroke due to intracerebral haemorrhage(RESTART):a randomised,open-label trial[J].Lancet,2019,393(10 191):2613-2623.[23] WHITELEY W N,SLOT K B,FERNANDES P,eta1. Risk factors for intracranial hemorrhage in acuteischemic stroke patients treated with recombinanttissue plasminogen activator:a systematic reviewand meta-analysis of 55 studies[J]. Stroke,2012,43(111):2904-2909.[24] 中华医学会神经病学分会与中华医学会神经病学分会脑血管病学组. 中国急性脑梗死后出血转化诊治共识2019[J]. 中华神经科杂志,2019,52(4):252-265.[25] KUDO K,SASAKI M,YAMADA K,et al.Differences in CT perfusion maps generated bydifferent commercial software:quantitative analysisby using identical source data of acute strokepatients[J]. Radiology,2010,254(1):200-209.[26] YASSI N,PARSONS M W,CHRISTENSENS,et al. Prediction of poststroke hemorrhagictransformation using computed tomographyperfusion[J]. Stroke,2013,44(11):3039-3043.[27] SHI F,GONG X,LIU C,et al. Acute stroke:prognostic value of quantitative collateral assessmentat perfusion CT[J]. Radiology,2019,290(3):760-768.[28] EL NAWAR R,YEUNG J,LABREUCHE J,et al.MRI-based predictors of hemorrhagic transformation inpatients with stroke treated by intravenousthrombolysis[J]. Front Neurol,2019,10(6):897.[29] SCALZO F,ALGER J R,HU X,et a1. Multicenterprediction of hemorrhagic transformation inacute ischemic stroke using permeability imagingfeatures[J]. Magn Reson Imaging,2013,31(6):961-969.[30] CAMPBELL B C,CHRISTENSEN S,BUTCHERK S,et a1. Regional very low cerebral blood volumepredicts hemorrhagic transformation better thandiffusion-weighted imaging volume and thresholdedapparent diffusion coefficient in acute ischemicstroke[J]. Stroke,2010,41(1):82-88.[31] CHARIDIMOU A,SHOAMANESH A,International META-MICROBLEEDS Initiative.Clinical relevance of microbleeds in acute strokethrombolysis[J]. Neurology,2016,87(15):1534-1541.[32] TURC G,SALLEM A,MOULIN S,et al.Microbleed status and 3-month outcome afterintravenous thrombolysis in 717 patients with acuteischemic stroke[J]. Stroke,2015,46(9):2458-2463.[33] KELLY P J,MORROW J D,NING M,et al.Oxidative stress and matrix metalloproteinase-9 inacute ischemic stroke:the Biomarker Evaluationfor Antioxidant Therapies in Stroke(BEAT-Stroke)study[J]. Stroke,2008,39(1):100-104.[34] TURNER R J,SHARP F R. Implications of MMP9for blood brain barrier disruption and hemorrhagictransformation following ischemic stroke[J]. FrontCell Neurosci,2016,10(6):56.[35] FOERCH C,WUNDERLICH M T,DVORAKF,et al. Elevated serum S100B levels indicate ahigher risk of hemorrhagic transformation afterthrombolytic therapy in acute stroke[J]. Stroke,2007,38(9):2491-2495.[36] LUGER S,WITSCH J,DIETZ A,et al. Glialfibrillary acidic protein serum levels distinguishbetween intracerebral hemorrhage and cerebralischemia in the early phase of stroke[J]. Clin Chem,2017,63(1):377-385.[37] MAESTRINI I,STRBIAN D,GAUTIER S,etal. Higher neutrophil counts before thrombolysisfor cerebral ischemia predict worse outcomes[J].Neurology,2015,85(16):1408-1416.[38] LEE J H,PARK K Y,SHIN J H,et al. Symptomatichemorrhagic transformation and its predictors inacute ischemic stroke with atrial fibrillation[J]. EurNeurol,2010,64(4):193-200.[39] GORI A M,GIUSTI B,PICCARDI B,et al.Inflammatory and metalloproteinases profiles predictthree-month poor outcomes in ischemic stroketreated with thrombolysis[J]. J Cereb Blood FlowMetab,2017,37(9):3253-3261.[40] KANAZAWA M,IGARASHI H,KAWAMURAK,et al. Inhibition of VEGF signaling pathwayattenuates hemorrhage after tPA treatment[J]. JCereb Blood Flow Metab,2011,31(6):1461-1474.[41] SOBRINO T,MILLAN M,CASTELLANOS M,et al. Association of growth factors with arterialrecanalization and clinical outcome in patientswith ischemic stroke treated with tPA[J]. J ThrombHaemost,2010,8(7):1567-1574.[42] RODRIGUEZ-YANEZ M,CASTELLANOS M,BLANCO M,et al. Micro and macroalbuminuriapredict hemorrhagic transformation in acuteischemic stroke[J]. Neurology,2006,67(7):1172-1177.[43] KASE C S,FURLAN A J,WECHSLER L R,et al. Cerebral hemorrhage after intra-arterialthrombolysis for ischemic stroke:the PROACT Ⅱtrial[J]. Neurology,2001,57(9):1603-1610.[44] LEE J H,PARK K Y,SHIN J H,et al. Symptomatichemorrhagic transformation and its predictors inacute ischemic stroke with atrial fibrillation[J]. EurNeurol,2010,64(4):193-200.[45] YANG N,LIN M,WANG B G,et al. Low levelof low-density lipoprotein cholesterol is relatedwith increased hemorrhagic transformation afteracute ischemic cerebral infarction[J]. Eur Rev MedPharmacol Sci,2016,20(4):673-678.[46] LIU,J,WANG D,XIONG Y,et al. Low freetriiodothyronine levels are related to symptomaticintracranial hemorrhage and poor functionaloutcomes after intravenous thrombolysis in acuteischemic stroke patients[J]. Neurol Res,2016,38(5):429-433. |
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