Progress in Key Influence Factors of Stem Cell Transplantation for the Treatment of Intracerebral Hemorrhage

Abstract

Abstract:

In recent years, stem cell-based approaches have attracted more attention from scientists and clinicians due to their possible therapeutical effect on intracerebral hemorrhage(ICH). Preclincal studies have demonstrated that the beneficial effects of stem cells on ICH. The stem cells include embryonic stem cells(ESCs), inducible pluripotent stem cells(iPSCs), neural stem cells (NSCs), and mesenchymal stem cell(MSCs). Their underlying mechanisms might be due to cell replacement, neurotrophic and neuroprotection, angiogenesis, and modulation on inflammation and immune response. Although several clinical studies have shown the high efficiency and safety of stem cell in ICH management, some key factors such stem cell type, cell dose, time window, and optimal cell transplantation approach remain to be addressed. According to the latest researches, this paper summarizes the advances in terms of these factors to provide a valuable reference for future research.

Key words: Intracranial hemorrhage; Stem cell; Key factors

摘要：

近年脑出血的干细胞治疗策略因其良好的前景吸引了越来越多基础和临床研究工作者的兴趣。临床前研究表明移植诸如胚胎干细胞、诱导多能干细胞、神经干细胞和间充质干细胞等均可获得不错的疗效，并揭示了脑出血后干细胞移植治疗起效的可能机制有细胞替代、神经营养与保护、促血管生成、免疫炎症反应调节等。尽管临床研究也表明干细胞治疗脑出血安全有效，但影响干细胞移植治疗的几大关键因素尚未确定，例如移植的细胞类型、细胞数量、移植时间、最佳给药途径、最佳受众人群以及如何追踪细胞等。本文根据最新研究成果就以上关键影响因素的研究进展作一综述，为后续研究提供有价值的参考。

关键词: 脑出血; 干细胞; 关键因素

ZHANG Qian, HU Rong, ZHENG Jiang, et al.. Progress in Key Influence Factors of Stem Cell Transplantation for the Treatment of Intracerebral Hemorrhage[J]. Chinese Journal of Stroke, 2015, 10(10): 890-895.

张倩，胡荣，郑江，冯华. 干细胞移植治疗脑出血的关键影响因素研究进展[J]. 中国卒中杂志, 2015, 10(10): 890-895.

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