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Table of Content

    20 December 2018, Volume 13 Issue 12
    Relay Race
    WANG Yong-Jun
    2018, 13(12):  1233-1236.  DOI: 10.3969/j.issn.1673-5765.2018.12.001
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    Application of Transcranial Doppler in Interventional Department
    XU Xiao-Tong, MA Ning
    2018, 13(12):  1237-1242.  DOI: 10.3969/j.issn.1673-5765.2018.12.002
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    The Predictive Value of Posterior Circulation Computed Tomography Angiography Score in Outcome of Mechanical Thrombectomy for Acute Basilar Artery Occlusion
    YANG Hai-Hua, MA Ning, LIU Lian, MO Da-Peng, GAO Feng, MIAO Zhong-Rong
    2018, 13(12):  1243-1250.  DOI: 10.3969/j.issn.1673-5765.2018.12.003
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    Objective To assess and validate the value of posterior circulation computed tomography angiography (pc-CTA) score in predicting the clinical outcome of mechanical thrombectomy in patients with acute basilar artery occlusion (BAO) using cerebral digital subtraction angiography (DSA). 

    Methods The clinical and angiographic data of 86 consecutive patients with acute BAO were retrospectively analyzed. The pc-CTA score was used to assess thrombus burden. Successful recanalization was defined as thrombolysis in cerebral infarction (TICI) score 2b/3. Favorable outcome was defined as a modified Rankin scale (mRS) score of 0-2 at 3 months. Receiver operating characteristic (ROC) curve was used to determine the area under the curve (AUC) and the optimal cutoff value. Multivariate logistic regression analysis was used to identify the independent predictor of clinical outcome at 3 months.

    Results A total of 86 acute BAO patients who had undergone mechanical thrombectomy were identified: 78 (90.7%) achieved successful recanalization (TICI 2b/3) and 30 (34.9%) had a favorable outcome (mRS 0-2). The univariate analysis showed that there was significant difference in the pc-CTA score between favorable outcome and poor outcome groups (P =0.005). ROC analysis indicated that the AUC of the pc-CTA score was 0.681 [95% confidence interval (CI) 0.572-0.778], and the optimal cutoff value was 2 (sensitivity: 53.33%, specificity: 80.36%). The multivariate logistic regression analysis showed that the pc-CTA score ≤2 could independently predict the 3-month favorable outcome in acute BAO patients treated with mechanical thrombectomy (odds ratio 3.831; 95%CI 1.302-11.273, P =0.015). 

    Conclusions The pc-CTA score may independently predict the short clinical outcome in acute BAO patients treated with thrombectomy.

    Effectiveness Analysis of Community-based Different Mass Stroke Risk Factors Screening and Management in Nanchang City
    LIU Xing-Yuan, DENG You-Qing, CHEN Xiao-Hong, ZHOU Feng, ZENG Mei-Hong, LI Huan-Huan, YU Shu-Qin, WEI Wen-Hua
    2018, 13(12):  1251-1255.  DOI: 10.3969/j.issn.1673-5765.2018.12.004
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    Objective To investigate the effectiveness of community-based stroke risk factors screening and standardized management in Nanchang city, and to understand the prevalence of high risk population of stroke in different population in Nanchang area. 

    Methods Stroke risk factors were evaluated by questionnaire and physical examination in rural inhabitants, urban inhabitants, and teachers in different communities of in Nanchang city. The people who had more than three risk factors were considered as high-risk people of stroke. The high-risk people were given 3-year of standardized management including changing the life style and/or drugs intervention. The risk factors were re-assessed after 3 years to evaluate the effect of these intervention.

    Results Of 746 rural inhabitants who participated in the screening, 177 (23.72%) were at high risk, and the mean score of risk factor assessment by questionnaire was (3.30±0.59). Of 1005 urban inhabitants who participated in the screening, 281 (27.96%) were at high risk, and the mean score of risk factor assessment was (3.68±0.78). Of 1359 teachers having undergone the screening, 172 (12.66%) were at high risk, and the mean score was (3.21±0.51). All the high-risk subjects were given standardized management, and their risk factors and prognosis including new-onset stroke and death were re-evaluated after 3 years. After 3 years, of the rural inhabitants, 5 people occurred new-onset stroke, 5 died from stroke, 1 died from other disease, 19 high-risk persons improved into non-high risk ones by intervention, and their mean score of risk factor assessment dropped to (2.97±0.55) (P <0.001); of urban inhabitants, 5 people occurred new-onset stroke, 5 died from recurrent stroke, 88 highrisk persons improved into non-high risk ones, their mean score decreased to (2.75±0.72) (P <0.001); of teachers, 2 persons occurred new-onset stroke, 1 person died from recurrent stroke, 59 high-risk persons improved into non-high risk ones, and their mean score declined to (2.81±0.78) (P <0.001). A total of 51 persons underwent artery stenting for symptomatic intracranial and/or extracranial arterial stenosis, 8 persons underwent aneurysm embolization for intracranial aneurysms. The top three risk factors in rural inhabitants were dyslipidemia (72.88%), hypertension (58.19%) and obesity (46.33%); the three ones in urban inhabitants were hypertension (77.22%), dyslipidemia (58.36%) and obesity (54.80%); and the three ones in teachers were lack of exercise (86.05%), dyslipidemia (84.84%) and hypertension (62.79%). 

    Conclusions The difference in the prevalence of high-risk people and the distribution of high risk factors in different population may be related to dietary structure and education level; and standardized management achieved a good effect in high-risk individuals in different population. These findings demonstrated the feasibility and usefulness of community-based stroke risk factors screening and management.

    Prevalence of Myxomatous Cerebral Aneurysms in Patients with Left Atrial Myxoma
    LIU Long-Qi, ZHAO Yuan-Li, SU Yi-Bing, WANG Hao, YE Xun, CHEN Xiao-Lin, MA Li, WANG Ke-Da
    2018, 13(12):  1256-1261.  DOI: 10.3969/j.issn.1673-5765.2018.12.005
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    Objective To investigate the prevalence of multiple myxomatous intracranial aneurysms in patients with a history of left atrial myxoma (LAM). 

    Methods Patients who had undergone surgery for LAM in Beijing Anzhen hospital from January 2001 to December 2009 were enrolled in this study, who met the inclusion criteria included: the diagnosis of LAM was proved by pathology after operation of LAM; and patients had undergone the whole cerebral digital subtraction angiography (DSA), or computed tomography angiography (CTA), or magnetic resonance angiography (MRA). 

    Results A total of 83 patients were identified, and medical data after surgery were obtained by telephone in 48 (58%) patients. Of the 48 patients, 3 (6%) patients had died and one of them died from cerebral hemorrhage due to ruptured myxomatous cerebral aneurysm at 3 years after surgery. Of the rest (n =45), 32 patients refused the imaging examination and 13 ones (10 females; mean age 42 years old) underwent DSA, CTA or MRA. 2 of the 13 cases were diagnosed with myxomatous intracranial aneurysm. The two patients plus that one died from myxomatous intracranial aneurysm rupture, the prevalence of myxomatous intracranial aneurysm in LAM patients was 21% (3/14). 

    Conclusions LAM patients have a high risk of occurring myxomatous intracranial aneurysm, however further research is needed.

    Sensibility and Reliability of the Gait Analysis System Based on the Sound and Motion Sensors
    KONG You-Qi, LIU Ming-Yong, WANG Cheng, ZHOU Li-Chun, WANG Xiang-Dong
    2018, 13(12):  1262-1265.  DOI: 10.3969/j.issn.1673-5765.2018.12.006
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    Objective To investigate the reliability and sensitivity of the gait analysis system based on the sound and motion sensors. 

    Methods 47 subjects were recruited in this gait analysis, including 22 stroke patients with hemiplegia and 25 healthy subjects. The gait parameters of all the subjects were recorded and compared to investigate the sensitivity of this system. The subjects were detected twice by the same doctor, and the intraclass correlation coefficient (ICC) was used to evaluate the reliability of the gait analysis system. 

    Results The kinematic parameters (stride length, walking speed, walking frequency, stride period, stance duration, double support duration and the angle of ankle) of the two groups showed significant differences. ICCs values of the gait parameters ranged from 0.901 to 0.996, which suggested a good test-retest reliability. 

    Conclusions The gait analysis system based on the sound and motion sensors has a good sensitivity and reliability.

    Therapeutic Effect of Speech Training Combined with Scalp Acupuncture in Stroke Patients with Aphasia: A Retrospective Analysis
    CHEN Qiu-Hong, LIU Liang, ZHAI Yan-Ping, LI Li, ZHU Yi
    2018, 13(12):  1266-1270.  DOI: 10.3969/j.issn.1673-5765.2018.12.007
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    Objective To explore the therapeutic effect of speech training combined with scalp acupuncture in improving speech, cognitive function and activities of daily living in stroke patients with aphasia. 

    Methods A retrospective analysis was made on 90 patients with apoplectic aphasia admitted to rehabilitation department and neurology department of our hospital from January 2016 to January 2017. They were divided into speech training combined with scalp needle group, speech training group and control group. Speech training combined with scalp needle group and speech training group served as observation groups, and compared before and after treatment. The functional recovery after treatment for 1 month and 3 months, and the long-term therapeutic effect at 9 months after discontinuation of treatment were evaluated by Barthel index (BI), Montreal cognitive assessment (MoCA) and aphasia quotient. 

    Results (1) The BI, MoCA score and aphasia quotient of each group were all improved after 1 month and 3 months of treatment and at 9 months after ceasing treatment. (2) MoCA scores and aphasia quotient of the two observation groups both showed continuous improvement after treatment (P <0.001). (3) MoCA score and aphasia quotient of speech training combined with scalp needle group were better than that of speech training group and control group (P <0.05); the BI of speech training combined with scalp needle group was better than that of speech training group after 3 months of treatment (P <0.05).

    Conclusions Speech training combined with scalp needle rehabilitation therapy can obviously improve speech and cognitive impairment, and improve activities of daily living more better in a short term.

    Progress in Predictors of Clinical Outcome in Acute Basilar Artery Occlusion Treated with Mechanical Thrombectory
    YANG Hai-Hua, MIAO Zhong-Rong
    2018, 13(12):  1272-1276.  DOI: 10.3969/j.issn.1673-5765.2018.12.008
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    Acute basilar artery occlusion usually leads to high mortality and disability rate. The new generation of thrombectomy devices application can reduce mortality and improve clinical outcome of acute basilar artery occlusion. However, the clinical outcome of acute basilar artery occlusion after mechanical thrombectomy is influenced by many factors, including age, time from onset to puncture, the severity of stroke, the size of infarct volume before treatment, thrombus burden, and collateral circulation and etc. This article reviewed the progress in endovascular treatment and clinical prognosis predictors of acute basilar artery occlusion.

    The Effects of Lysophosphatidic Acid in Atherosclerotic Lesion
    ZHANG Jian-Ping, LI Ya-Feng, GUO Geng
    2018, 13(12):  1277-1281.  DOI: 10.3969/j.issn.1673-5765.2018.12.009
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    Atherosclerosis is a severe and chronic inflammatory arterial disease that can lead to coronary heart disease, ischemic stroke and etc. Lysophosphatidic acid (LPA) plays a crucial role in the progression of atherosclerotic lesion by acting on endothelial cells, vascular smooth muscle cells, monocytes/macrophages, fibroblasts, dendritic cells, T-lymphocytes and platelets, which promotes atherosclerosis and thrombosis. Studies on the effects and pathophysiologic mechanisms of LPA in the atherosclerosis can contribute to find potential drugs and prevention measures for anti-atherosclerosis.

    Stroke: 3-year Restenosis Rate After Intracranial Angioplasty and Stenting in the SAMMPRIS Trial
    YANG Zhong-Hua
    2018, 13(12):  1282-1282.  DOI: 10.3969/j.issn.1673-5765.2018.12.010
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    JNS: Perioperative Management of Antiplatelet Drugs in Patients Undergoing Neuroendovascular Procedures
    YANG Zhong-Hua
    2018, 13(12):  1283-1283.  DOI: 10.3969/j.issn.1673-5765.2018.12.011
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    Dural Arteriovenous Fistulas: 3 Cases Report and Literature Review
    ZHANG Xiao-Wei, LU Li-Jun, LI Xin-Ming, ZHOU Feng, TAN Yu, CHEN Xiao-Hong, DENG You-Qing
    2018, 13(12):  1291-1295.  DOI: 10.3969/j.issn.1673-5765.2018.12.013
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    Successful Low-dose Intravenous Alteplase Thrombolysis in One Patient with Acute Ischemic Stroke after Kidney Biopsy: A Case Report and Literature Review
    LIU Lin, LIU Yue-Ming, CHEN Mao-Sheng, HE Qiang
    2018, 13(12):  1296-1298.  DOI: 10.3969/j.issn.1673-5765.2018.12.014
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    Stenting for Symptomatic Intracranial Arterial Stenosis in China: 1-year Outcome of A Multicenter Registry Study
    MA Ning
    2018, 13(12):  1299-1300.  DOI: 10.3969/j.issn.1673-5765.2018.12.015
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    Progress of Symptomatic Intracranial Hemorrhage after Intravenous Thrombolysis in Ischemic Stroke
    LIANG Zhi-Gang, YANG Shao-Wan, YU Guo-Ping
    2018, 13(12):  1301-1308.  DOI: 10.3969/j.issn.1673-5765.2018.12.016
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    Bleeding transformation, especially symptomatic intracranial hemorrhage is an uncommon but serious complication after intravenous thrombolysis in the acute phase of ischemic stroke, which can lead to high disability and mortality. Thrombolysis rate of acute stroke in China was far lower than that in Europe and the United States, the main cause of which was for fear of hemorrhagic transformation risk. This article reviewed the symptomatic hemorrhage after thrombolysis, to provide a reference for safer thrombolytic therapy of acute stroke.

    Progress of Correlation of Migraine and Ischemic Stroke
    CUI Shu-Hui, CHEN Ning, HE Li
    2018, 13(12):  1309-1315.  DOI: 10.3969/j.issn.1673-5765.2018.12.017
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    The previous studies have demonstrated migraine may be a risk factor of ischemic stroke. Neuroimaging studies also suggested that migraine is associated with brain structural abnormality. However, the specific pathophysiological mechanism of migraine in ischemic cerebrovascular diseases is still unclear. The possible etiology and pathogenesis include that external factors (such as migraine drugs and lifestyle etc.), endothelial dysfunction and coagulation abnormalities, cortical spreading depression, etc. This article reviewed that the advance in epidemiology, neuroimaging and genetics of migraine increasing the risk of ischemic stroke, and the possible pathophysiologic mechanism involved.

    Progress of F Wave and H Reflex in Effect Evaluation of Antispastic Treatment of Limb Spasticity in Post-stroke Patients
    LI Huan-Qin, LONG De-Huai, LI Bin, SUN Jing-Qing, WEN Ya-Li, LIU Yin-Xia, DU Hong-Yan, WANG Lin-Peng
    2018, 13(12):  1316-1320.  DOI: 10.3969/j.issn.1673-5765.2018.12.018
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    Spasticity of limbs in post-stroke patients is a common abnormal muscle tone characterized by an enhancement of spinal cord stretch reflex. This is caused by the upper motoneuron injury leading to the loss of spinal stretch reflex inhibition from high-level central nervous system. Limb spasticity can seriously affect the functional rehabilitation of post-stroke patients. In recent years, various anti-spastic therapies emerged, but the evaluation criteria of antispastic effect are different, and these criteria are mainly subjective ones. The objective evaluation indexes such as F wave and H reflection were often used in combination with the subjective evaluation scales to evaluate the anti-spastic effect in recent clinical studies. However, compared to H reflex, F wave is more sensitive and can reflect the changes of limb muscle tone better. Hence, at present the modified Ashworth Scale combined with F wave are often used to evaluate the effect of anti-spastic treatment in post-stroke patients.

    Advance in Treatment of Patent Foramen Ovale and Clinical Application of Paradoxical Embolism Risk Scale
    FAN Xue-Hui, ZHONG Di, CHEN Hong-Ping, LI Guo-Zhong, ZHAO Xiu-Li
    2018, 13(12):  1321-1326.  DOI: 10.3969/j.issn.1673-5765.2018.12.019
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    Stroke is the first cause of death in China, and cryptogenic stroke (CS) is a special kind of ischemic stroke. The cause of stroke is still not determined even after a thorough examination, such stroke is called CS. Abnormal embolism caused by patent foramen ovale (PFO) is the most likely cause of CS. In recent years, the treatment methods of CS with PFO have long been controversial. At the same time, the Risk of Paradoxical Embolism (RoPE) score, a new scale which can predict abnormal embolism risk, has become a hot issue at home and abroad. This article reviewed the current research on PFO treatment and clinical application of RoPE scale in PFO.

    Progress of SphK1/S1P Signaling Pathway in the Mechanism of Cerebral Ischemia Reperfusion Injury
    LI Shi,LYU Man-Hua
    2018, 13(12):  1327-1331.  DOI: 10.3969/j.issn.1673-5765.2018.12.020
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    Sphingomyelin and its metabolites [ceramide, sphingosine (Sph), sphingosine- 1-phosphate (S1P)] being important signaling molecules play an very important role in pathophysiological processes such as cell proliferation, survival, apoptosis and immune response. Sphingosine kinase (SphK) is a key enzyme catalyzing Sph to S1P. Cerebral ischemia reperfusion injury involves various mechanism such as excitotoxicity, neuroinflammation and oxidative stress, free radical production, blood brain barrier injure, vascular permeability alteration and cell apoptosis. This article introduced the functional characteristics of SphK1 and S1P, the effect of SphK1/S1P signaling pathway on nerve cell injury in cerebral ischemia reperfusion and the possible molecular mechanism.