不同神经心理症状与脑小血管病影像学关系的研究进展

doi:10.3969/j.issn.1673-5765.2024.04.003

中国卒中杂志 ›› 2024, Vol. 19 ›› Issue (4): 405-413.DOI: 10.3969/j.issn.1673-5765.2024.04.003

不同神经心理症状与脑小血管病影像学关系的研究进展

胡琨¹，管玲^2，3，王伊龙^{2，3，4，5，6，7，8}

1 北京 100069 首都医科大学附属北京佑安医院神经内科
2 国家神经疾病医学中心
3 首都医科大学人脑保护高精尖创新中心
4 首都医科大学附属北京天坛医院神经病学中心
5 北京脑科学与类脑研究中心
6 国家神经系统疾病临床医学研究中心
7 口腔健康北京实验室
8 临床流行病学北京市重点实验室

收稿日期:2023-12-13 出版日期:2024-04-20 发布日期:2024-04-20
通讯作者: 王伊龙 yilong528@aliyun.com
基金资助:
国家自然科学基金委员会杰出青年科学基金项目（81825007）
国家自然科学基金（82271516；81801187；82202085；72204169）
科技部国家重点研发计划（2022YFF1501500；2022YFF1501501；2022YFF1501502；2022YFF1501503；2022YFF1501504；2022YFF1501505）

Research Progress on the Relationship between Various Neuropsychological Symptoms and Imaging of Cerebral Small Vessel Disease

HU Kun¹, GUAN Ling^2,3, WANG Yilong^{2,3,4,5,6,7,8}

1 Department of Neurology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China;
2 National Center for Neurological Disorders, Beijing 100070, China;
3 Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100070, China;
4 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China;
5 Chinese Institute for Brain Research, Beijing 102206, China;
6 China National Clinical Research Center for Neurological Diseases, Beijing 100070, China;
7 Beijing Laboratory of Oral Health, Capital Medical University, Beijing 100069, China;
8 Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China

Received:2023-12-13 Online:2024-04-20 Published:2024-04-20
Contact: WANG Yilong, E-mail: yilong528@aliyun. com

摘要/Abstract

摘要： 脑小血管病（cerebral small vessel disease，CSVD）是由各种病因影响脑内小血管所导致的一系列临床、影像、病理学综合征，其在国际上尚无统一诊断标准，症状轻微，故临床上主要根据神经影像学表现分为新近皮质下小梗死、假定血管源性腔隙、假定血管源性脑白质高信号、血管周围间隙、脑微出血、脑皮质表面铁沉积和脑萎缩。证据表明，CSVD可能与诸多神经心理学症状相关，然而，神经心理症状与CSVD发生和发展之间的关系目前尚不明确。本文对情感淡漠、疲劳、焦虑、抑郁和心理应激与CSVD影像学关系的研究进展进行了综述。

文章导读： 本文对CSVD的影像学特征及其伴有的神经心理学症状的相关性以及可能的发生机制进行了综述，为后续探索CSVD患者神经心理症状的神经病理学机制提供了参考。

关键词: 脑小血管病; 神经心理症状; 影像学特征

Abstract: Cerebral small vessel disease (CSVD) is a series of clinical, imaging and pathological syndrome caused by various causes affecting the small blood vessels in the brain. There is no unified diagnostic standard in the world for CSVD, and the symptoms are mild. Therefore, based on neuroimaging findings, it can be divided into recent small subcortical infarct, lacune of presumed vascular origin, white matter hyperintensity of presumed vascular origin, perivascular space, cerebral microbleed, cortical superficial siderosis, and brain atrophy. Evidence suggests that CSVD may be associated with a variety of neuropsychological manifestations. However, the relationship between neuropsychological symptoms and the occurrence and development of CSVD is not clear. In this paper, the research progress of the relationship between apathy, fatigue, anxiety, depression and psychological stress and the imaging of CSVD was reviewed.

Key words: Cerebral small vessel disease; Neuropsychological symptom; Imaging feature

中图分类号:

胡琨, 管玲, 王伊龙. 不同神经心理症状与脑小血管病影像学关系的研究进展[J]. 中国卒中杂志, 2024, 19(4): 405-413.

HU Kun, GUAN Ling, WANG Yilong. Research Progress on the Relationship between Various Neuropsychological Symptoms and Imaging of Cerebral Small Vessel Disease[J]. Chinese Journal of Stroke, 2024, 19(4): 405-413.

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不同神经心理症状与脑小血管病影像学关系的研究进展

Research Progress on the Relationship between Various Neuropsychological Symptoms and Imaging of Cerebral Small Vessel Disease

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[1]	王伊龙. 脑小血管病的诊治现状及未来探索之路[J]. 中国卒中杂志, 2024, 19(4): 363-374.
[2]	陈玮琪, 徐佳洁, 陆瑶, 王玲, 曹瑾怡, 陈鸿宾, 郭蕾, 吕琰琛, 汤晗, 王赞, 徐非凡, 颜庭梦, 应云清, 仲伟逸, 周蓉, 陆正齐, 程忻, 王伊龙, 中国卒中学会脑小血管病分会. 中国脑小血管病的神经影像学诊断标准及名词标准化定义——来自中国卒中学会的专家共识[J]. 中国卒中杂志, 2024, 19(4): 376-404.
[3]	杨营营, 王伊龙. 2013—2023年血管周围间隙相关研究的文献计量学分析[J]. 中国卒中杂志, 2024, 19(4): 414-422.
[4]	潘希娟, 邢英琦, 刘玉梅. 血管超声在脑小血管病中的应用进展[J]. 中国卒中杂志, 2024, 19(3): 343-348.
[5]	代杰, 张素响, 赵沙沙, 张晓凤. 脑小血管病患者认知障碍影响因素分析及列线图模型的构建与验证[J]. 中国卒中杂志, 2024, 19(10): 1136-1142.
[6]	祖煜, 于莎莎, 张玉婧, 吕晶, 冯雪丹. HTRA1基因杂合突变相关遗传性脑小血管病1例并文献复习[J]. 中国卒中杂志, 2023, 18(9): 1054-1059.
[7]	朱小鸳, 郝贵生. 脑小血管病与头晕症状关系的研究进展[J]. 中国卒中杂志, 2023, 18(8): 940-946.
[8]	陈嫄, 周玉颖, 李攀. 以精神行为异常为突出表现的遗传性脑小血管病1例报道[J]. 中国卒中杂志, 2023, 18(11): 1248-1254.
[9]	叶瑾怡, 王赞, 龚宇田, 郭蕾, 果彤, 胡琨, 陆瑶, 单舒乙, 王玲, 悦芳芳, 朱婧涵, 郑欣雅, 陈玮琪, 王伊龙. 脑小血管病研究的神经影像学标准STRIVE-2——自2013年以来的新进展[J]. 中国卒中杂志, 2023, 18(10): 1160-1174.
[10]	叶瑾怡, 陈玮琪, 王伊龙. 脑小血管病国际影像标准2更新要点解读[J]. 中国卒中杂志, 2023, 18(10): 1175-1180.
[11]	曾慧鈃, 李金标, 王猛, 欧阳馥冰, 禹雷, 易铭, 郭佳钰, 倪瑞晨, 崔立谦, 范玉华. 基于纤维束示踪的空间统计分析对脑小血管病合并阻塞性睡眠呼吸暂停患者脑微结构改变的研究[J]. 中国卒中杂志, 2023, 18(05): 503-513.
[12]	刘洋, 王蕊, 张祥, 孙慧玲, 马英虎. 症状性小动脉硬化脑小血管病患者脑微出血的危险因素分析[J]. 中国卒中杂志, 2023, 18(04): 440-449.
[13]	陈悦薇, 徐群. 脑小血管病的外周标志物及其多组学研究进展[J]. 中国卒中杂志, 2023, 18(03): 340-346.
[14]	王伊龙, 陈玮琪, 叶瑾怡, 周梦圆, 江凌玲, 刘东, 邱宝山, 高颖, 赵一龙, 王赞, 李鹏飞. 脑小血管病：回眸2022[J]. 中国卒中杂志, 2023, 18(01): 17-41.
[15]	田雨, 管玲, 王伊龙. 脑小血管病患者排尿功能紊乱与自主神经功能的相关性研究 [J]. 中国卒中杂志, 2023, 18(01): 76-82.