FGF23-Klotho内分泌轴对脑血管及卒中的影响综述

doi:10.3969/j.issn.1673-5765.2024.04.010

摘要/Abstract

摘要： 成纤维细胞生长因子23（fibroblast growth factor 23，FGF23）-Klotho内分泌轴参与磷酸盐代谢，研究提示该内分泌轴与卒中的发病机制密切相关。FGF23、Klotho水平均与卒中的发病及预后有关。FGF23-Klotho内分泌轴参与调节血管壁炎症反应，并可能参与高血压、胰岛素抵抗、脂代谢及肥胖等卒中危险因素的病理过程。本文介绍FGF23-Klotho内分泌轴对卒中的影响及可能机制的相关研究进展，以期为临床治疗和预防卒中带来新的思路。

文章导读： 体内磷酸盐稳态失衡可导致血管壁细胞内原位胆固醇合成，促进动脉粥样硬化，与卒中的发病相关。FGF23-Klotho内分泌轴参与维持磷酸盐稳态，是可能影响卒中发病和预后的潜在干预靶点。

关键词: 卒中; 成纤维细胞生长因子23; Klotho蛋白

Abstract: Fibroblast growth factor 23 (FGF23) -Klotho endocrine axis is involved in phosphate metabolism, and is closely related to the pathogenesis of stroke. FGF23 and Klotho levels are associated with the incidence and prognosis of stroke. The FGF23-Klotho endocrine axis is involved in the regulation of vascular inflammation and may be involved in the pathological process of stroke risk factors such as hypertension, insulin resistance, lipid metabolism and obesity. In this paper, the influence and mechanism of FGF23-Klotho endocrine axis on stroke were reviewed in order to bring new ideas for clinical treatment and prevention of stroke.

Key words: Stroke; Fibroblast growth factor 23; Klotho protein

中图分类号:

宋晓, 卢克良, 吴春艳. FGF23-Klotho内分泌轴对脑血管及卒中的影响综述[J]. 中国卒中杂志, 2024, 19(4): 468-473.

SONG Xiao, LU Keliang, WU Chunyan. A Review of the Effects of the FGF23-Klotho Endocrine Axis on Blood Vessels of Brain and Stroke[J]. Chinese Journal of Stroke, 2024, 19(4): 468-473.

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