关键词: 颈动脉狭窄; 认知功能损害; 血管成形术; 支架

Abstract: Objective To analyze the effect of carotid artery stenting(CAS) on cognitive function for thepatients with internal carotid artery(ICA) stenosis.Methods Total 116 patients with ICA stenosis were treated with carotid artery stenting. All thepatients were examined with mini-mental state examination(MMSE) and P300 before and aftertreatment of 1, 3 and 6 months.Results Technical success was achieved in all the patients, with no CAS-related complicationsduring periprocedure. The residual post-procedure stenosis was 4.5%±6.0%, with significantreduction from pre-procedure stenosis (84%±15%, P <0.01). Before the treatment the score ofMMSE and the latent phase of P300 were 20±5 and 434±78 ms, respectively. After treatment of 1,3 and 6 months the scores of MMSE were elevated significantly and the latent phases of P300 wereshortened significantly, especially on 6 months follow-up. The patients had no recurrent transientischemia attach(TIA) or stroke during the follow-up.Conclusion Carotid artery stenosis is related to cognitive impairment. Endovascular stenting forICA stenosis can improve cognitive function during short-term follow-up.

Key words: Carotid artery stenosis; Cognitive impairment; Angioplasty; Stenting