关键词: 心房颤动; 非瓣膜性; 脑梗塞; 发病机制

Abstract: Objective To study the pathogenesis of cerebrovascular disorders by analyzing the categories of cerebral infarct and the related risk factors of the NVAF patients. Methods From 2005 to 2007, we investigated the patients of cerebrovascular disorders of the NVAF in the first affiliated hospital of Fujian Medical University, and analyzed the categories of cerebral infarct and their related factors of NVAF and VAF by CT and MRI of brain. Results We found the same risk factors of the stroke patients with NVAF and VAF were heart failure and hyperfibrinogenemia, and the different factors were that the VAF-related cerebrovascular disorders was closely relation with the faster ventricular rate and the NVAF -related cerebrovascular disorders was closely related to hypertension, carotid plaques, diabetes mellitus and hyperlipemia(χ2=8.80, P=0.003; χ2=17.75, P<0.001; χ2=4.06, P<0.05; χ2=6.50, P=0.01). The distribution ratio of categories of them were different, and the reason of the stroke patients of the VAF was mainly aortic embolism(χ2=23.98, P<0.001), however, the NVAF was aortic embolism, cortical branch infarct, watershed infarct and lacunar infarct and so on, especially watershed infarct(χ2=15.08, P<0.001). Conclusion NVAF patients may suffer from a variety of cerebral infarctions, especially watershed infarct. In the meantime, they were closely related to the risk factors of atherosclerosis (including hypertension, hyperlipemia and hyperglycemia). We thought that hemodynamic changes may be one of the important pathogenesis of cerebral infarct.

Key words: 【Key Words】 Atrialfibrillation; non-valvular; Brain infarction; Pathogenesis