关键词: 支架; 脊髓损伤; 运动; 诱发电位; 运动

Abstract: Objective To assess the effects of directional poly-lactic-co-glycolicacid (PLGA) scaffoldstransplantation on hind limbs motor function after hemisected spinal cord injury (hSCI) in rats.Methods Female adult wistar rats were randomly divided into four groups: normal group (n=15);sham operation group (n=15); hSCI group (n=18) and PLGA group (n=15). The spinal cord washemisected in the rats of hSCI group. In PLGA group, the rats suffer the spianal cord hemisectedinjury and the directional PLGA scaffold was transplanted into the injury site. Inclined plane(IP)test, the Basso Beattie Bresnahan locomotor rating scale (BBB) score and motor evoked potentials(MEP) were adopted to assess hind limbs motor functional revival in 12 weeks after operation. Thestatistical data were tested by One-Way ANOVA analysis and LSD test.Results The inclined plane angle in PLGA group at 4 and 8 weeks after operation was higher thanthat in group hSCI: 4w (56.0±2.0) and (54.7±2.3), P =0.030; 8w (64.7±2.4) and (62.3±2.3), P =0.038;the BBB score in PLGA group is higher than that in hSCI at 4 weeks: (7.9±1.2) and (7.1±1.3),P =0.042; the motor evoked potential amplitude in PLGA group were significant difference than thatin group hCSI at 12 weeks: (29.9±11.0μV) and (21.4±10.4μV), P =0.039.Conclusion The directional PLGA scaffolds transplantation may improve the hind limbs motorfunction and the recovery of MEPs in rats with hSCI.

Key words: Scaffolds; Spinal cord injuries; Exercise; Evoked potentials; motor