关键词: 烟雾病; 栓塞; 微栓子信号; 脑梗死

Abstract: Objective To investigate the relationship between the microembolic signals(MESs) and the clinicalmanifestation and infarctions in patients with Moyamoya disease.Methods We reviewed 6 patients with Moyamoya disease in whom MESs was present duringtranscranial Doppler(TCD) test, to investigate the relationship between the MESs and the clinicalmanifestation and the distribution of infarctions on diffusion-weighted imaging(DWI).Results MES was present in the middle cerebral artery(MCA), 3(50%) of which are stenosis andothers are occlusive. Among the 6 patients, 5(83.33%) patients had recent clinical symptoms,3(50%) patients with symptoms compatible with ischemia in the MCA territory without MESs,1(16.67%) patient with symptoms in MCA territory with and without MESs, and 1(16.67%) patientwith symptoms in the posterior circulation. From DWI, 5/6(83.33%) patients showed infarctions,4(66.67%) patients showed infarctions in the MCA territory with MESs, and 5(83.33%) patientsshowed infarctions in the MCA territory without MESs. All the patients had multiple infarcts.Cortical infarcts were the most common.Conclusion MES can be detected in patients with Moyamoya disease, with or without recent symptoms.The relationship between MES and clinical manifestation and infarctions needs further study.

Key words: Moyamoya disease; Embolism; Microembolic signals; Cerebral ischemia