1 Hacket t ML，Pickles K. Par t Ⅰ：f requency of

depression after stroke：an updated systematic review

and meta-analysis of observational studies[J]. Int J

Stroke，2014，9：1017-1025.

2 Hackett ML，Yapa C，Parag V，et al. Frequency

of depression after stroke：a systematic review of

observational studies[J]. Stroke，2005，36：1330-1340.

3 Bilge C，Koçer E，Koçer A，et al. Depression

and functional outcome after stroke：the effect of

antidepressant therapy on functional recovery[J]. Eur

J Phys Rehabil Med，2008，44：13-18.

4 Paolucci S，Grasso MG，Antonucci G，et al. Oneyear

follow-up instroke patients discharged from

rehabilitation hospital[J]. Cerebrovasc Dis，2000，10：

25-32.

5 Feigin VL，Barker-Collo S，Krishnamurthi R，et al.

Epidemiology of ischaemic stroke and traumatic brain

injury[J]. Best Pract Res Clin Anaesthesiol，2010，24：

485-494.

6 House A，Knapp P，Bamford J，et al. Mortality at 12

and 24 months after stroke may be associated with

depressive symptoms at 1 month[J]. Stroke，2001，32：

696-701.

7 Williams LS，Ghose SS，Swindle RW. Depression

and other mental health diagnoses increase mortality

risk after ischemic stroke[J]. Am J Psychiatry，2004，

161：1090-1095.

8 Robinson RG，Jorge RE. Post-stroke depression：a

review[J]. Am J Psychiatry，2016，173：221-231.

9 World Health Organization. International statistical

classification of diseases and related health problems，

Tenth Revision (ICD-10)[J]. Encyclopedia of Clinical

Neuropsychology，2009，1：107-110.

10 American Psychiatric Association. Diagnostic and

statistical manual of mental disorders[M]. 5th edition.

Arlington，VA：American Psychiatric Publishing，

2013.

11 中华医学会精神科分会. CCMD-3中国精神障碍分类

与诊断标准[M]. 济南：山东科学技术出版社，2001.

12 Robinson RG，Kubos KL，Starr LB，et al. Mood

disorders in stroke patients. Importance of location of

lesion[J]. Brain，1984，107：81-93.

13 Starkstein SE，Robinson RG，Price TR. Comparison

of cortical and subcortical lesions in the production of

poststroke mood disorders[J]. Brain，1987，110：1045-

1059.

14 Provinciali L，Coccia M. Post-stroke and vascular

depression：a critical review[J]. Neurol Sci，2002，22：

417-428.

15 Zhang T，Jing X，Zhao X，et al. A prospective cohort

study of lesion location and its relation to post-stroke

depression among Chinese patients[J]. J Affect Disord，

2012，136：e83-e87.

16 Ny s GM，van Zandvoor t MJ，va n der Wor p

HB，et al . Early depressive symptoms af ter

stroke：neuropsychological correlates and lesion

characteristics[J]. J Neurol Sci，2005，228：27-33.

17 Santos M，Gold G，Kövari E，et al. Differential

impact of lacunes and microvascular lesions on

poststroke depression[J]. Stroke，2009，40：3557-3562.

18 Andersen G，Vestergaard K，Ingemann-Nielsen M，

et al. Risk factors for post-stroke depression[J]. Acta

Psychiatr Scand，1995，92：193-198.

19 Tang WK，Tang N，Liao CD，et al. Serotonin receptor

2C gene polymorphism associated with post-stroke

depression in Chinese patients[J]. Genet Mol Res，

2013，12：1546-1553.

20 Bryer JB，Starkstein SE，Votypka V，et al. Reduction

of CSF monoamine metabolites in postst roke

depression：a preliminary report[J]. J Neuropsychiatry

Clin Neurosci，1992，4：440-442.

21 Gao HQ，Zhu HY，Zhang YQ，et al. Reduction of

cerebrospinal fluid and plasma serotonin in patients

with post-stroke depression：A preliminary report[J].

Clin Invest Med，2008，31：E351-356.

22 吕路线，宋景贵，卢红，等. 卒中后抑郁状态患者的血

浆、脑脊液单胺类神经递质测定[J]. 中华精神科杂志，

2000，33：29-32.

23 Loubinoux I，Kronenberg G，Endres M，et al. Poststroke

depression：mechanisms，translation and

therapy[J]. J Cell Mol Med，2012，16：1961-1969.

24 Bruggimann L，Annoni JM，Staub F，et al. Chronic

posttraumatic stress symptoms after nonsevere

stroke[J]. Neurology，2006，66：513-516.

25 Cojocaru GR，Popa-Wagner A，Stanciulescu EC，et

al. Post-stroke depression and the aging brain[J]. J

Mol Psychiatry，2013，1：14.

26 Hadidi N，Treat-Jacobson DJ，Lindquist R. Poststroke

depression and functional outcome：a critical review

of literature[J]. Heart Lung，2009，38：151-162.

27 Parikh RM，Robinson RG，Lipsey JR，et al. The

impact of poststroke depression on recovery in

activities of daily living over a 2-year follow-up[J].

Arch Neurol，1990，47：785-789.

28 House A. Depression associated with stroke[J]. J

Neuropsychiatry Clin Neurosci，1996，8：453-457.

29 Göthe F，Enache D，Wahlund LO，et al. Cerebrovascular

diseases and depression：epidemiology，mechanisms

and treatment[J]. Panminerva Med，2012，54：161-170.

30 Townend BS，Whyte S，Desborough T，et a l.

Longitudinal prevalence and determinants of early

mood disorder post-stroke[J]. J Clin Neurosci，2007，

14：429-434.

31 Jaracz K，Kozubski W. The role of social support in

the quality of life after stroke. A review of selected

experimental research[J]. Neurol Neurochir Pol，2006，

40：140-150.

32 季建林. 重视医患关系，提高沟通技能[J]. 内科理论与

实践，2011，6：167-170.

33 Kroenke K，Spitzer RL，Williams JB. The PHQ-

9：validity of a brief depression severity measure[J]. J

Gen Intern Med，2001，16：606-613.

34 Hamilton M. A rating scale for depression[J]. J Neurol

Neurosurg Psychiatry，1960，23：56-62.

35 Montgomery SA，Asberg M. A new depression scale

designed to be sensitive to change[J]. Br J Psychiatry，

1979，134：382-389.

36 Zung WW. A Self-Rating Depression Scale[J]. Arch

Gen Psychiatry，1965，12：63-70.

37 Beck AT，Steer RA. Beck depression inventory：

manual[M]. San Antonio，TX：Psychological

Corporation，1987.

38 Hamilton M. Hamilton Rating Scale for Depression

(Ham-D)//Handbook of psychiatric measures[M].

Washington DC：APA，2000：526-528.

39 Brink TL，Yesavage JA，Lum O，et al. Screening

t e s t s for ge r iat r ic depr e s s ion[J ]. C l i n ica l

Gerontologist，1982，1：37-43.

40 Sutcliffe LM，Lincoln NB. The assessment of

depression in aphasic stroke patients：the development

of the Stroke Aphasic Depression Questionnaire[J].

Clin Rehabil，12：506-513.

41 Montgomery SA，Asberg M. Mongomery-Asberg

depression rating scale//Handbook of psychiatric

measures[M]. Washington，DC：APA，2000：531-533.

42 Radloff LS. The CES-D. A Self-Report Depression

Scale for research in the general population[J].

Applied Psychological Measurement，1977，1：385-

401.

43 Zigmond AS，Snaith RP. The hospital anxiety and

depression scale[J]. Acta Psychiatr Scand，1983，67：

361-370.

44 Barth J，Munder T，Gerger H，et al. Comparative

efficacy of seven psychotherapeutic interventions for

patients with depression：a network meta-analysis[J].

PLoS Med，2013，10：e1001454.

45 Eskes GA，Lanctôt KL，Herrmann N，et al. Canadian

Stroke Best Practice Recommendations：Mood，

Cognition and Fatigue Following Stroke practice

guidelines，update 2015[J]. Int J Stroke，2015，10：

1130-1140.

46 Wannagat W，Zielasek J，Gaebel W. Therapy of poststroke

depression-a systematic review[J]. Psychiatrie，

2013，10：108-129.

47 Mead GE，Hsieh CF，Lee R，et al. Selective serotonin

reuptake inhibitors for stroke recovery：a systematic

review and meta-analysis[J]. Stroke，2013，44：844-

850.

48 Cipr i a n i A，Fur ukawa TA，Salant i G，e t a l .

Comparative efficacy and acceptability of 12 newgeneration

antidepressants：a multiple-treatments

meta-analysis[J]. Lancet，2009，373：746-758.