症状性颅内外血管不同狭窄程度微栓子
阳性率研究

摘要/Abstract

摘要：

【摘要】目的研究颅内外血管不同狭窄程度和闭塞时微栓子的阳性率差异。方法连续选取症状性颅内外血管狭窄并除外存在同侧颅内外血管串联狭窄的患者，按责任血管分为颈内动脉狭窄、大脑中动脉狭窄和椎-基底动脉狭窄3组，按照责任血管的狭窄程度分为轻度、中度、重度狭窄和闭塞组。所有患者行经颅多普勒超声（transcranial Doppler sonography，TCD）检测病变侧微栓子，比较各组间微栓子阳性率的差异。结果研究期间共227例入组，颈内动脉狭窄组73例、大脑中动脉狭窄组126例、椎-基底动脉狭窄组28例，3组的微栓子阳性率分别为34.25%（25/73）、38.89%（49/126）、39.29%（11/28），无显著差异。中度狭窄组及重度狭窄组的微栓子阳性率高于轻度狭窄组（P <0.001）及闭塞组（P <0.001），轻度狭窄组与闭塞组栓子阳性率无显著差异。结论中、重度颅内外血管狭窄者易发生微栓子的脱落，轻度狭窄组与血管闭塞组微栓子阳性率较低。

文章导读： 本研究通过经颅多普勒对微栓子进行检测，发现症状性颅内外血管狭窄患者中，中重度动脉狭窄
者微栓子阳性率高于轻度狭窄和动脉闭塞患者。

关键词: 微栓子; 血管狭窄; 症状性; 缺血性卒中

Abstract:

【Abstract】 Objective To study and compare microembolic signal (MES) incidence in different degree artery stenosis in symptomatic intracranial and extracranial artery stenosis. Methods The patients diagnosed symptomatic intracranial or extracranial artery stenosis were recruited while the patients who have tandem stenosis in the intracranial and extracranial artery and potential embolic source were excluded. All the enrolled patients were divided into carotid artery stenosis group or middle cerebral artery stenosis group or vertebral-basilar artery stenosis group. In each group, they were further divided into different groups on the basis of the degree of the stenosed artery: mild stenosis group, middle stenosis group, severe stenosis group and occlusive group. And the frequency of MES was compared among the different groups. Results Two hundred and twenty seven patients were recruited in the study (including 73 symptomatic internal carotid stenosis, 126 symptomatic middle cerebral artery stenosis and 28 symptomatic vertebral-basilar artery stenosis). The MES incidence of the three groups were 34.25% (25/73), 38.89% (49/126) and 39.29% (11/28). There is no difference in MES incidence among the three groups (P >0.05). Further we divided all the symptomatic stenosis arteries into mild, middle, severe stenosis and occlusive group. By comparing the MES incidence, we found that the middle stenosis group and severe stenosis group were higher than the mild stenosis group (P <0.01) and the occlusive group (P <0.01). But there is no difference in the MES incidence between the mild stenosis group and the occlusive group (P >0.05). Conclusion MES is more frequently seen in patients with middle or severe vascular stenosis while the mild and occlusion groups have a low frequency of MES.

Key words: Microembolous; Artery stenosis, Symptomatic; Ischemic stroke

吴秀娟1，刘亢丁2，杨弋2，王峥峥2，邢英琦1. 症状性颅内外血管不同狭窄程度微栓子
阳性率研究[J]. 中国卒中杂志, 2014, 9(03): 188-192.

WU Xiu-Juan*, LIU Kang-Ding, YANG Yi,WANG Zheng-Zheng, XING Ying-Qi.. Relationship between Microembolous and Artery Stenosis Degree in Symptomatic
Intracranial and Extracranial Artery Stenosis[J]. Chinese Journal of Stroke, 2014, 9(03): 188-192.

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