非痴呆性血管性认知障碍的研究进展

doi:10.3969/j.issn.1673-5765.2017.12.020

摘要/Abstract

摘要：

血管性认知障碍（vascular cognitive impairment，VCI）是由脑血管病危险因素（如高血压、糖尿病、高脂血症和高同型半胱氨酸血症等）、显性脑血管病（出血性及缺血性卒中）及非显性脑血管病（脑白质疏松和慢性脑缺血等）引起的一组从轻度认知功能损害到痴呆的临床综合征。非痴呆性血管性认知障碍（vascular cognitive impairment-no dementia，VCIND）是VCI的早期阶段，其中约一半患者会在5年内进展为痴呆。血管性痴呆（vascular dementia，VD）在治疗上尚未发现行之有效的方法，但又是唯一可以预防的痴呆。发现VCIND危险因素并进行早期干预，对于寻求延缓痴呆进展的二级预防策略至关重要。现从VCIND的概念、流行病学、诊断标准及影响因素等方面进行综述，以期能够早期识别相关危险因素，防治VCI。

文章导读： 本文对非痴呆性血管性认知障碍的概念、流行病学、诊断标准及影响因素等方面的研究进展做了综述，以期对非痴呆性血管性认知障碍进行早期识别、研究及干预治疗，防治血管性认知障碍。

关键词: 非痴呆性血管性认知障碍; 概念; 流行病学; 诊断标准; 影响因素

Abstract:

Vascular cognitive impairment (VCI) is a group of clinical syndromes from mild cognitive impairment to dementia, caused by cerebrovascular disease risk factors (such as high blood pressure, diabetes, hyperlipidemia and high homocysteine levels, etc), the dominant cerebrovascular disease (hemorrhagic and ischemic stroke) and the non-dominant cerebrovascular disease (leukoaraiosis and chronic cerebral hypoperfusion, etc). Vascular cognitive impairmentno dementia (VCIND) is an early stage of VCI, of which about half of patients will progress to dementia within 5 years. The effective treatment of vascular dementia (VD) has not yet been found, but it's the only type of dementia that can be prevented. The discovery of risk factors of VCIND and early intervention is critical for secondary prevention strategies seeking to slow or delay dementia progression. The concept, epidemiology, diagnostic criteria and influencing factors of VCIND are reviewed in order to identify relevant risk factors and prevent vascular cognitive impairmen

Key words: Vascular cognitive impairment-no dementia; Concept; Epidemiology; Diagnostic criteria; Influencing factors

陈红霞，郭姗姗，武一平，宋彦丽，林杰. 非痴呆性血管性认知障碍的研究进展[J]. 中国卒中杂志, 2017, 12(12): 1148-1153.

CHEN Hong-Xia,GUO Shan-Shan, WU Yi-Ping, SONG Yan-Li, LIN Jie. The Research Progress of Vascular Cognitive Impairment-no Dementia[J]. Chinese Journal of Stroke, 2017, 12(12): 1148-1153.

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