Clinical Efficacy Observation of Butylphthalide Injection on Patients with Acute Ischemic Stroke

doi:10.3969/j.issn.1673-5765.2017.11.008

Abstract

Abstract:

Objective To observe and explore the efficacy of butylphthalide injection on patients with acute cerebral infarction. Methods A total of 128 patients who were diagnosed with acute cerebral infarction and hospitalized in our hospital from February 2013 to December 2014 were randomly selected as study subjects. There were 75 cases in conventional group and 53 cases in the group of conventional therapy combined with butylphthalide peptide sodium chloride injection. The neurological impairment, the level of high sensitivity C-reactive protein (hsCRP) and lysophosphatidic acid (LPA) in two groups before and after treatment were compared. Results There was no significant difference in National Institutes of Health stroke scale (NIHSS) between two groups before treatment. The scores of NIHSS of two groups after treatment both decreased significantly comparing with that of respective group before treatment. The NIHSS score of treatment group was significantly lower than that of conventional group. The hsCRP and LPA levels of two groups after treatment decreased significantly than that of respective group before treatment, and the levels in treatment group were significantly lower than that in conventional group. Conclusion Butyphthalide injection combined therapy had better effect in reducing neurological deficit, hsCRP level and LPA level in patients with acute cerebral infarction comparing with conventional therapy.

Key words: Butylphthalide; Cerebral infarction; Prognosis; Inflammatory factor

摘要：

目的观察丁苯酞注射液联合方案对急性脑梗死（cerebral infarction，CI）的治疗效果。方法收集2013年2月-2014年12月确诊为急性CI并住院治疗的128例患者为研究对象。分为常规组（常规治疗）75例和治疗组（常规治疗联合丁苯酞）53例。对两组患者治疗前后的美国国立卫生研究院卒中量表（National Institutes of Health Stroke Scale，NIHSS）、血清超敏C反应蛋白（high sensitivity C-reactive protein，hsCRP）和溶血磷脂酸（lysophosphatidic acid，LPA）水平进行比较。结果两组患者治疗前NIHSS评分无显著差异，治疗后治疗组NIHSS为（4.02±1.36）分，常规组为（7.69±2.53）分，较本组治疗前均有显著降低，且治疗组显著低于常规组。治疗后两组hsCRP、LPA含量均显著低于本组治疗前，且治疗组显著低于常规组。结论丁苯酞注射液联合方案与常规治疗方案相比，能更有效地改善急性CI患者的神经系统功能，且能降低患者血清hsCRP、LPA水平。

关键词: 丁苯酞; 脑梗死; 预后; 炎性因子

LI Chun-Xiang, ZHAO Li-Xia, Qin Hua-Hong. Clinical Efficacy Observation of Butylphthalide Injection on Patients with Acute Ischemic Stroke[J]. Chinese Journal of Stroke, 2017, 12(11): 1010-1012.

李春祥，赵丽霞，覃华宏. 丁苯酞注射液对急性脑梗死疗效观察[J]. 中国卒中杂志, 2017, 12(11): 1010-1012.

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