Abstract:

Objective To investigate the effect of butylphthalide injection on matrix metalloproteinase-9 and the volume of acute massive cerebral infarction. Methods A total of 58 cases with acute massive cerebral infarction were randomly divided into control group (n =29) and treatment group (n =29). The control group was given conventional treatment of cerebral infarction, and the treatment group was given butylphthalide injection based on the conventional treatment. Two groups of patients underwent magnetic resonance imaging (MRI) scan on admission (first day), third day and tenth day, respectively. The cerebral infarction volume were measured. The serum matrix metalloproteinase-9 levels were detected at 12 hours, 48 hours, 72 hours after onset of disease. Results Comparing with the control group, the infarct volume of the treatment group at third day [(144.09±29.41) cm3 vs (170.21±33.09) cm3] and tenth day [(116.57±25.73) cm3 vs (140.21±29.48) cm3] were significantly reduced, which had statistical significance. Comparing with the control group, the serum matrix metalloproteinase-9 level decreased significantly in the treatment group at 48th hour and 72th hour after the onset of disease [48 h: (212.69±10.51) ng/ml vs (247.79±8.25) ng/ml); 72 h: (86.14±4.84)ng/ml vs (106.10±7.03) ng/ml], which had statistical significance. Conclusion Butylphthalide injection can decrease the expression of matrix metalloproteinases-9 and reduce the volume of acute massive cerebral infarction.

Key words: Butylphthalide; Massive cerebral infarction; Matrix metalloproteinase

摘要：

目的 研究丁苯酞注射液对急性大面积脑梗死体积及血清基质金属蛋白酶- 9（m a t r i x metalloproteinases-9，MMP-9）水平的影响。 方法 将58例急性大面积脑梗死患者随机分为对照组和治疗组各29例，对照组予以脑梗死常规治 疗，治疗组在常规治疗基础上加用丁苯酞注射液。两组患者分别在入院时、入院3 d和10 d行头颅磁 共振成像（magnetic resonance imaging，MRI），测量脑梗死体积，分别在发病12 h、48 h、72 h检测血清 MMP-9的水平。 结果 与对照组相比，治疗组入院3 d [（144.09±29.41）cm3 vs（170.21±33.09）cm3]及10 d （[ 116.57±25.73）cm3 vs（140.21±29.48）cm3]脑梗死体积缩小，差异有统计学意义。与对照组相比， 治疗组发病后48 h（[ 212.69±10.51）ng/ml vs（247.79±8.25）ng/ml）]及72 h（[ 86.14±4.84）ng/ml vs （106.10±7.03）ng/ml] MMP-9水平下降，差异有统计学意义。 结论 丁苯酞注射液可以降低急性期大面积脑梗死患者MMP-9的表达，缩小脑梗死体积。

关键词: 丁苯酞; 大面积脑梗死; 基质金属蛋白酶