Chinese Journal of Stroke ›› 2025, Vol. 20 ›› Issue (8): 935-941.DOI: 10.3969/j.issn.1673-5765.2025.08.001
Previous Articles Next Articles
ZHOU Hongyu, LI Zixiao, WANG Chunjuan
Received:
2025-04-16
Revised:
2025-07-19
Accepted:
2025-07-25
Online:
2025-08-20
Published:
2025-08-20
Contact:
WANG Chunjuan, E-mail: wangchunjuan@ncrcnd.org.cn
周宏宇,李子孝,王春娟
通讯作者:
王春娟 wangchunjuan@ncrcnd.org.cn
基金资助:
CLC Number:
ZHOU Hongyu, LI Zixiao, WANG Chunjuan. Full-Course Closed-Loop Management for Neurological Disorders through Artificial Intelligence-Powered Terminal Devices[J]. Chinese Journal of Stroke, 2025, 20(8): 935-941.
周宏宇, 李子孝, 王春娟. 人工智能赋能终端设备驱动的神经系统疾病全病程闭环管理[J]. 中国卒中杂志, 2025, 20(8): 935-941.
[1] GBD 2021 Nervous System Disorders Collaborators. Global,regional,and national burden of disorders affecting the nervous system,1990-2021:a systematic analysis for the global burden of disease study 2021[J]. Lancet Neurol,2024,23(4):344-381. [2] ERICKSON C M,WEXLER A,LARGENT E A. Digital biomarkers for neurodegenerative disease[J]. JAMA Neurol,2025,82(1):5-6. [3] RICOTTI V,KADIRVELU B,SELBY V,et al. Wearable full-body motion tracking of activities of daily living predicts disease trajectory in Duchenne muscular dystrophy[J]. Nat Med,2023,29(1):95-103. [4] KADIRVELU B,GAVRIEL C,NAGESHWARAN S,et al. A wearable motion capture suit and machine learning predict disease progression in Friedreich’s ataxia[J]. Nat Med,2023,29(1):86-94. [5] DONNER E,DEVINSKY O,FRIEDMAN D. Wearable digital health technology for epilepsy[J]. N Engl J Med,2024,390(8):736-745. [6] CHEN C R,DING S C,WANG J. Digital health for aging populations[J]. Nat Med,2023,29(7):1623-1630. [7] BUTLER P M,YANG J,BROWN R,et al. Smartwatch and smartphone-based remote assessment of brain health and detection of mild cognitive impairment[J]. Nat Med,2025,31(3):829-839. [8] CAI T A,NI H M,YU M L,et al. DeepStroke:an efficient stroke screening framework for emergency rooms with multimodal adversarial deep learning[J/OL]. Med Image Anal,2022,80:102522[2025-04-10]. https://doi.org/10.1016/j.media.2022.102522. [9] NEVLER N,CHO S,COUSINS K A Q,et al. Changes in digital speech measures in asymptomatic carriers of pathogenic variants associated with frontotemporal degeneration[J/OL]. Neurology,2024,102(2):e207926[2025-04-10]. https://doi.org/10.1212/wnl.0000000000207926. [10] JEONG S M,SONG Y D,SEOK C L,et al. Machine learning-based classification of Parkinson’s disease using acoustic features:insights from multilingual speech tasks[J/OL]. Comput Biol Med,2024,182:109078[2025-04-10]. https://doi.org/10.1016/j.compbiomed.2024.109078. [11] SÁNCHEZ-SÁNCHEZ M L,RUESCAS-NICOLAU M A,ARNAL-GÓMEZ A,et al. Validity of an android device for assessing mobility in people with chronic stroke and hemiparesis:a cross-sectional study[J/OL]. J Neuroeng Rehabil,2024,21(1):54[2025-04-10]. https://doi.org/10.1186/s12984-024-01346-5. [12] SCHÖNHERR C,ZIEGLER J,ZENTEK T,et al. Smartphone-based gait analysis in the assessment of fatigue and fatigability in people with multiple sclerosis:a supervised cohort study[J/OL]. J Neurol,2025,272(3):217[2025-07-10]. https://doi.org/10.1007/s00415-025-12906-7. [13] VELUVALI A,DEHGHANI ZAHEDANI A,HOSSEINIAN A,et al. Impact of digital health interventions on glycemic control and weight management[J/OL]. NPJ Digit Med,2025,8(1):20[2025-07-10]. https://doi.org/10.1038/s41746-025-01430-7. [14] KÓKAI L L,Ó CEALLAIGH D,WIJTZES A I,et al. App-based physical activity intervention among women with prior hypertensive pregnancy disorder:a randomized clinical trial[J/OL]. JAMA Netw Open,2025,8(4):e252656[2025-07-10]. https://doi.org/10.1001/JAMAnetworkopen.2025.2656. [15] BEDI S,LIU Y,ORR-EWING L,et al. Testing and evaluation of health care applications of large language models:a systematic review[J]. JAMA,2025,333(4):319-328. [16] RAO S,LI Y K,MAMOUEI M,et al. Refined selection of individuals for preventive cardiovascular disease treatment with a transformer-based risk model[J/OL]. Lancet Digit Health,2025,7(6):100873[2025-07-10]. https://doi.org/10.1016/j.landig.2025.03.005. [17] ATES H C,NGUYEN P Q,GONZALEZ-MACIA L,et al. End-to-end design of wearable sensors[J]. Nat Rev Mater,2022,7(11):887-907. [18] ZHOU S,PARK G,LONGARDNER K,et al. Clinical validation of a wearable ultrasound sensor of blood pressure[J]. Nat Biomed Eng,2025,9(6):865-881. [19] HUGHES M S,ADDALA A,BUCKINGHAM B. Digital technology for diabetes[J]. N Engl J Med,2023,389(22):2076-2086. [20] SPATZ E S,GINSBURG G S,RUMSFELD J S,et al. Wearable digital health technologies for monitoring in cardiovascular medicine[J]. N Engl J Med,2024,390(4):346-356. [21] LOHSE K R,MILLER A E,BLAND M D,et al. Association between real-world actigraphy and poststroke motor recovery[J]. Stroke,2025,56(8):2079-2090. [22] SCHALKAMP A K,PEALL K J,HARRISON N A,et al. Wearable movement-tracking data identify Parkinson’s disease years before clinical diagnosis[J]. Nat Med,2023,29(8):2048-2056. [23] ZHAO H,CHEN W C,LI Y H,et al. In situ structural-functional synchronous dissection of dynamic neuromuscular system via an integrated multimodal wearable patch[J/OL]. Sci Adv,2025,11(2):eads1486[2025-07-10]. https://doi.org/10.1126/sciadv.ads1486. [24] GILL S K,BARSKY A,GUAN X,et al. Consumer wearable devices for evaluation of heart rate control using digoxin versus beta-blockers:the RATE-AF randomized trial[J]. Nat Med,2024,30(7):2030-2036. [25] SHAH K,WANG A R,CHEN Y W,et al. Automated loss of pulse detection on a consumer smartwatch[J]. Nature,2025,642(8066):174-181. [26] SINGH B,CHASTIN S,MIATKE A,et al. Real-world accuracy of wearable activity trackers for detecting medical conditions:systematic review and meta-analysis[J/OL]. JMIR Mhealth Uhealth,2024,12:e56972[2025-04-10]. https://doi.org/10.2196/56972. [27] OEHRN C R,CERNERA S,HAMMER L H,et al. Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson’s disease:a blinded randomized feasibility trial[J]. Nat Med,2024,30(11):3345-3356. [28] FRIEDRICH M U,RELTON S,WONG D,et al. Computer vision in clinical neurology:a review[J]. JAMA Neurol,2025,82(4):407-415. [29] YANG Y Z,YUAN Y,ZHANG G,et al. Artificial intelligence-enabled detection and assessment of Parkinson’s disease using nocturnal breathing signals[J]. Nat Med,2022,28(10):2207-2215. [30] HAQUE A,MILSTEIN A,FEI-FEI L. Illuminating the dark spaces of healthcare with ambient intelligence[J]. Nature,2020,585(7824):193-202. [31] ZHANG Y,LIU X Y,QIAO X F,et al. Characteristics and emerging trends in research on rehabilitation robots from 2001 to 2020:bibliometric study[J/OL]. J Med Internet Res,2023,25:e42901[2025-04-10]. https://doi.org/10.2196/42901. [32] KILGARD M P,EPPERSON J D,ADEHUNOLUWA E A,et al. Closed-loop vagus nerve stimulation aids recovery from spinal cord injury[J]. Nature,2025,643(8073):1030-1036. [33] XIA H S,ZHANG Y C,RAJABI N,et al. Shaping high-performance wearable robots for human motor and sensory reconstruction and enhancement[J/OL]. Nat Commun,2024,15(1):1760[2025-07-10]. https://doi.org/10.1038/s41467-024-46249-0. [34] HANKOV N,CABAN M,DEMESMAEKER R,et al. Augmenting rehabilitation robotics with spinal cord neuromodulation:a proof of concept[J/OL]. Sci Robot,2025,10(100):eadn5564[2025-07-10]. https://doi.org/10.1126/scirobotics.adn5564. [35] SHEN J,YU J H,ZHANG H,et al. Artificial intelligence-powered social robots for promoting physical activity in older adults:a systematic review[J/OL]. J Sport Health Sci,2025,14:101045[2025-07-10]. https://doi.org/10.1016/j.jshs.2025.101045. [36] DOSSO J A,BANDARI E,MALHOTRA A,et al. Towards emotionally aligned social robots for dementia:perspectives of care partners and persons with dementia[J/OL]. Alzheimers Dement,2022,18 Suppl 2:e059261[2025-04-10]. https://doi.org/10.1002/alz.059261. [37] CHEN S W,FAN S C,QIAO Z,et al. Transforming healthcare:intelligent wearable sensors empowered by smart materials and artificial intelligence[J/OL]. Adv Mater,2025,37(21):e2500412[2025-07-10]. https://doi.org/10.1002/adma.202500412. [38] PHIPPS J,PASSAGE B,SEL K,et al. Early adverse physiological event detection using commercial wearables:challenges and opportunities[J/OL]. NPJ Digit Med,2024,7(1):136[2025-04-10]. https://doi.org/10.1038/s41746-024-01129-1. [39] XIAO X,YIN J Y,XU J,et al. Advances in machine learning for wearable sensors[J]. ACS Nano,2024,18(34):22734-22751. [40] LIU J J,BORSARI B,LI Y,et al. Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations[J]. Cell,2025,188(2):515-529. [41] THANGARAJ P M,BENSON S H,OIKONOMOU E K,et al. Cardiovascular care with digital twin technology in the era of generative artificial intelligence[J]. Eur Heart J,2024,45(45):4808-4821. [42] ZHANG W S,LING Y,CHEN Z L,et al. Wearable sensor-based quantitative gait analysis in Parkinson’s disease patients with different motor subtypes[J/OL]. NPJ Digit Med,2024(7):169[2025-04-10]. https://doi.org/10.1038/s41746-024-01163-z. [43] YU B S,KAKU A,LIU K N,et al. Quantifying impairment and disease severity using AI models trained on healthy subjects[J/OL]. NPJ Digit Med,2024(7):180[2025-04-10]. https://doi.org/10.1038/s41746-024-01163-z. [44] LEE M,YEO N Y,AHN H J,et al. Prediction of post-stroke cognitive impairment after acute ischemic stroke using machine learning[J/OL]. Alzheimers Res Ther,2023,15(1):147[2025-04-10]. https://doi.org/10.1186/s13195-023-01289-4. [45] STEVELINK R,AL-TOMA D,JANSEN F E,et al. Individualised prediction of drug resistance and seizure recurrence after medication withdrawal in people with juvenile myoclonic epilepsy:a systematic review and individual participant data meta-analysis[J/OL]. EClinicalMedicine,2022,53:101732[2025-04-10]. https://doi.org/10.1016/j.eclinm.2022.101732. [46] TAN J,GONG E Y,GALLIS J A,et al. Primary care-based digital health-enabled stroke management intervention:long-term follow-up of a cluster randomized clinical trial[J/OL]. JAMA Netw Open,2024,7(12):e2449561[2025-04-10]. https://doi.org/10.1001/jamanetworkopen.2024.49561. [47] DHAMIJA R K,SALUJA A,GARG D,et al. Teleneurorehabilitation and motor and nonmotor symptoms and quality of life in Parkinson disease:the TELEPARK randomized clinical trial[J]. JAMA Neurol,2025,82(4):376-383. [48] BISWAS M,SABA L,OMERZU T,et al. A review on joint carotid intima-media thickness and plaque area measurement in ultrasound for cardiovascular/stroke risk monitoring:artificial intelligence framework[J]. J Digit Imaging,2021,34(3):581-604. [49] CHEN E,PRAKASH S,JANAPA REDDI V,et al. A framework for integrating artificial intelligence for clinical care with continuous therapeutic monitoring[J]. Nat Biomed Eng,2025,9(4):445-454. [50] GUTERUD M,FAGERHEIM BUGGE H,RØISLIEN J,et al. Prehospital screening of acute stroke with the National Institutes of Health stroke scale(ParaNASPP):a stepped-wedge,cluster-randomised controlled trial[J]. Lancet Neurol,2023,22(9):800-811. [51] CUI F F,HE X Y,ZHAI Y K,et al. Application of telemedicine services based on a regional telemedicine platform in China from 2014 to 2020:longitudinal trend analysis[J/OL]. J Med Internet Res,2021,23(7):e28009[2025-04-10]. https://doi.org/10.2196/28009. [52] SHENG Y Y,BOND R,JAISWAL R,et al. Augmenting K-means clustering with qualitative data to discover the engagement patterns of older adults with multimorbidity when using digital health technologies:proof-of-concept trial[J/OL]. J Med Internet Res,2024,26:e46287[2025-04-10]. https://doi.org/10.2196/46287. [53] GHASSEMI M,OAKDEN-RAYNER L,BEAM A L. The false hope of current approaches to explainable artificial intelligence in health care[J/OL]. Lancet Digit Health,2021,3(11):e745-e750[2025-04-10]. https://doi.org/10.1016/s2589-7500 (21) 00208-9. [54] GINSBURG G S,PICARD R W,FRIEND S H. Key issues as wearable digital health technologies enter clinical care[J]. N Engl J Med,2024,390(12):1118-1127. [55] BAYOUMY K,GABER M,ELSHAFEEY A,et al. Smart wearable devices in cardiovascular care:where we are and how to move forward[J]. Nat Rev Cardiol,2021,18(8):581-599. [56] ZINZUWADIA A,SINGH J P. Wearable devices-addressing bias and inequity[J/OL]. Lancet Digit Health,2022,4(12):e856-e857[2025-04-10]. https://doi.org/10.1016/s2589-7500 (22) 00194-7. [57] HERNANDEZ-BOUSSARD T,LEE A Y,STOYANOVICH J,et al. Promoting transparency in AI for biomedical and behavioral research[J]. Nat Med,2025,31(6):1733-1734. [58] SADÉE C,TESTA S,BARBA T,et al. Medical digital twins:enabling precision medicine and medical artificial intelligence[J/OL]. Lancet Digit Health,2025:100864[2025-07-10]. https://doi.org/10.1016/j.landig.2025.02.004. [59] 马锐华. 从头再来 揭开脑卒中患者出院后管理的秘密[M]. 北京:科学技术文献出版社,2025:249-255. MA R H. Starting anew:unveiling the secrets of post-discharge management for stroke patients[M]. Beijing:Scientific and Technical Documentation Press,2025:249-255. [60] CHEN R J,WANG J J,WILLIAMSON D F K,et al. Algorithmic fairness in artificial intelligence for medicine and healthcare[J]. Nat Biomed Eng,2023,7(6):719-742. [61] WILLIAMS C Y K,SUBRAMANIAN C R,ALI S S,et al. Physician- and large language model-generated hospital discharge summaries[J]. JAMA Intern Med,2025,185(7):818-825. [62] TU T,SCHAEKERMANN M,PALEPU A,et al. Towards conversational diagnostic artificial intelligence[J]. Nature,2025,642(8067):442-450. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||