Progress of Clinical Research of Leukoaraiosis

Abstract

Abstract:

【Abstract】 The previous studies suggested that leukoaraiosis(LA) may be associated with older age, hypertension, diabetes, hyperhomocysteinemia and other risk factors. There is no clear conclusion about specific correlation. Researches on the pathogenesis of LA mainly focus on low perfusion, destruction of blood-brain barrier, while studies about the gene of LA are also one of the hot spots. But all of this lack of recognized and positive findings. This article reviews the advances and controversies of risk factors and pathogenesis of LA.

Key words: Leukoaraiosis; Risk factors; Pathogenesis

摘要：

【摘要】既往研究认为脑白质疏松（leukoaraiosis，LA）可能与高龄、高血压、糖尿病、高同型半胱氨酸血症等危险因素有关，但其具体相关性尚无明确结论。关于LA发病机制的研究多集中在低灌注、血脑屏障破坏上，基因的研究也是热点之一，但都尚缺乏公认的肯定研究结果。本文对LA危险因素和发病机制的研究进展和争议进行了综述。

关键词: 脑白质疏松; 危险因素; 发病机制

ZHAO Ping, WANG Chun-Xue, ZHANG Yu-Mei, SHI Qing-Li. Progress of Clinical Research of Leukoaraiosis[J]. Chinese Journal of Stroke, 2013, 8(06): 491-495.

赵萍，王春雪，张玉梅，石庆丽. 脑白质疏松的危险因素及发病机制研究进展[J]. 中国卒中杂志, 2013, 8(06): 491-495.

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