Advance of Perfusion Imaging in Predicting Hemorrhagic Transformation after
Thrombolytic Therapy for Acute Ischemic Stroke

Abstract

Abstract:

Hemorrhagic transformation (HT) is a serious complication of ischemic stroke. The mechanism of HT is thought to be endothelial injury and blood-brain barrier disruption due to severe ischemia. Recent studies have demonstrated that perfusing imaging is useful in the pretreatment prediction of HT, and is more strongly associated and may allow better prediction of HT when compared with CT or diffusion imaging. This article reviews the studies that evaluated different perfusion imaging parameters as predictors of HT in acute ischemic stroke with the aim to facilitate obtaining the reliable therapy strategies for acute ischemic stroke and improving patient selection for acute reperfusion therapy.

Key words: Stroke; Ischemic; Thrombolysis; Hemorrhagic transformation; Blood-brain barrier; Perfusion imaging

摘要：

出血转化是缺血性卒中的常见并发症之一，其中溶栓治疗导致继发性出血转化风险明显增加是困扰临床医生的重要问题。目前认为血脑屏障的破坏在出血转化的发生中起到关键的作用。近来研究显示，急性期的灌注影像检查对于出血转化高风险人群检出可能具有更高的敏感性和其他优势。本文针对灌注成像在预测急性缺血性卒中患者溶栓后出血转化的研究进展方面做一综述。

关键词: 卒中; 缺血性; 溶栓; 出血转化; 血脑屏障; 灌注成像

CHEN Ke-Nan, GUO Shun-Yuan,GENG Yu.. Advance of Perfusion Imaging in Predicting Hemorrhagic Transformation after
Thrombolytic Therapy for Acute Ischemic Stroke[J]. Chinese Journal of Stroke, 2015, 10(02): 165-169.

陈珂楠，郭舜源，耿昱. 脑灌注成像预测溶栓后出血转化风险的研究进展[J]. 中国卒中杂志, 2015, 10(02): 165-169.

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