Progress of Vascular Parkinsonism

doi:10.3969/j.issn.1673-5765.2018.09.021

Abstract

Abstract:

Vascular pakinsonism (VP) is a kind of secondary parkinsonism based on cerebrovascular disease. The symptoms and cognitive impairment of VP are different from those of primary Parkinson's disease. The pathogenesis of VP is not clear, which may be related to subcortical cerebral ischemia and neurotransmitter changes. Currently it is believed that factors associated with its pathogenesis may include risk factors of cerebrovascular disease, white matter lesions, basal ganglia ischemia, and etc. This article reviewed the epidemiology, pathogenesis, clinical features, and influencing factors of VP, to provide reference for physicians and improve the quality of life of patients.

Key words: Vascular parkinsonism; Epidemiology; Pathogenesis; Clinical symptoms;Influencing factors

摘要：

血管性帕金森综合征（vascular pakinsonism，VP）是脑血管病基础上的一类继发性帕金森综合征，其症状及认知障碍特点与原发帕金森病有所区别。VP的发病机制尚未明确，可能与皮质下脑缺血及神经代谢递质变化有关。目前认为与其发病相关的因素可能包括脑血管病危险因素、脑白质病变、基底节缺血等。本文就VP的流行病学、发病机制、临床特征、影响因素等方面进行综述，以期为临床诊治提供帮助，改善患者生存质量。

关键词: 血管性帕金森综合征; 流行病学; 发病机制; 临床症状; 影响因素

GUO Shan-Shan, CHEN Hong-Xia, WU Yi-Ping, LIN Jie. Progress of Vascular Parkinsonism[J]. Chinese Journal of Stroke, 2018, 13(09): 990-994.

郭姗姗, 陈红霞, 武一平, 林杰. 血管性帕金森综合征的研究进展[J]. 中国卒中杂志, 2018, 13(09): 990-994.

References

[1] LIU W. Vascular Parkinsonism[J]. Cerebrovascular

Diseases Foreign Medical Sciences，2004，333（5）：

513-524.

[2] MANOSALVA H A，PIO F，Jeerakathil T，et al.

Vascular Parkinsonism in a Tertiary Care Stroke

Prevention Clinic and the Development of a New

Screening Strategy[J]. J Stroke Cerebrovasc Dis，

2018，27（1）：153-161.

[3] LEVIN O S，CHIMAGOMEDOVA A S，

SKRIPKINA N A，et al. Nonmotor Symptoms in

Vascular and Other Secondary Parkinsonism[J/OL].

International Review of Neurobiology，2017，134：

1303-1334. https：//doi.org/10.1016/bs.irn.2017.05.016.

[4] CASLAKE R，TAYLOR K，SCOTT N，et al.

Age-，and gender-specific incidence of vascular

parkinsonism，progressive supranuclear palsy，and

parkinsonian-type multiple system atrophy in North

East Scotland：the PINE study[J]. Parkinsonism &

Related Disorders，2014，20（8）：834-839.

[5] 中华医学会神经病学分会帕金森病及运动障碍学组.

中国血管性帕金森综合征诊断与治疗专家共识[J].

全科医学临床与教育，2017，50（4）：364-367.

[6] MURROW R W，SCHWEIGER G D，KEPES J J，et

al. Parkinsonism due to a basal ganglia lacunar state：

clinicopathologic correlation[J]. Neurology，1990，40

（6）：897-900.

[7] YAMANOUCHI H，NAGURA H. Neurological

Signs and Frontal White Matter Lesions in Vascular

Parkinsonism A Clinicopathologic Study[J]. Stroke，

1997，28（5）：965-969.

[8] XU Y，WEI X，LIU X，et al. Low Cerebral Glucose

Metabolism：A Potential Predictor for the Severity of

Vascular Parkinsonism and Parkinson's Disease[J].

Aging & Disease，2015，6（6）：426-436.

[9] HERBERT M K，KUIPERIJ H，BLOEM B R，et

al. Levels of HVA，5-HIAA，and MHPG in the CSF

of vascular parkinsonism compared to Parkinson's

disease and controls[J]. J Neurology，2013，260（12）：

3129-3133.

[10] DUNET V，DEVERDUN J，CHARROUD C，et al.

Cognitive Impairment and Basal Ganglia Functional

Connectivity in Vascular Parkinsonism[J]. AJNR

Am J Neuroradiol，2016，37（12）：2310-2316.

[11] BENÍTEZRIVERO S，PALOMAR F J，

MARTÍNRODRÍGUEZ J F，et al. Abnormal

sensorimotor integration correlates with cognitive

profile in vascular parkinsonism[J/OL]. J Neurolo

Sci，2017，377：161-166. https：//doi.org/10.1016/

j.jns.2017.03.050.

[12] ZIJLMANS J C，DANIEL S E，HUGHES A J，et

al. Clinicopathological investigation of vascular

parkinsonism，including clinical criteria for

diagnosis[J]. Movement Disorders，2004，19（6）：

630-640.

[13] AKYOL A，AKYILDIZ U O，TATAROGLU C.

Vascular Parkinsonism：a case of lacunar infarction

localized to mesencephalic substantia nigra[J].

Parkinsonism & Related Disorders，2006，12（7）：

459-461.

[14] KATZENSCHLAGER R，ZIJLMANS J，EVANS

A，et al. Olfactory function distinguishes vascular

parkinsonism from Parkinson’s disease[J]. J Neurol

Neurosurg Psychiatry，2004，75（12）：1749-1752.

[15] 苏立静，徐俊，马甲. 血管性帕金森综合征56例临床

分析[J]. 现代实用医学，2016，28（4）：448-450.

[16] BENAMER H T S，GROSSET D G. Vascular

Parkinsonism：A Clinical Review[J]. European

Neurology，2009，61（1）：11-15.

[17] Korczyn A D. Vascular parkinsonism-characteristics，

pathogenesis and treatment[J]. Nature Reviews

Neurology，2015，11（6）：319.

[18] SIBON I，FENELON G，QUINN N P，et al.

Vascular parkinsonism[J]. J Neurol，2004，251（5）：

513-524.

[19] GLASS P G，LEES A J，BACELLAR A，et al. The

clinical features of pathologically confirmed vascular

parkinsonism[J]. J Neurol Neurosurg Psychiatry，

2012，83（10）：1027-1029.

[20] DJALILOVA S，IBODULLAYEV Z，

MAMADALIYEV A，et al. Comparative analysis

of cognitive and affective disorders in vascular

parkinsonism and Parkinson’s disease[J].

Parkinsonism & Related Disorders，2016，22（2）：

e122.

[21] COLOSIMO C，MORGANTE L，ANTONINI A，et

al. Non-motor symptoms in atypical and secondary

parkinsonism：the PRIAMO study[J]. J Neurology，

2010，257（1）：5-14.

[22] 郭丽花，胡如英，龚巍巍，等. 脑卒中危险因素研究

进展[J]. 中国老年学，2017，37（17）：251-254. [23] 赵德强. 血管性帕金森综合征与帕金森病临床特点

及影像学的对比研究[J]. 南方医科大学学报，2005，

25（7）：868-870.

[24] VLASOV V，DARWEESH S K L，STRICKER B

H，et al. Subclinical vascular disease and the risk of

parkinsonism：The rotterdam study[J]. Parkinsonism

Relat Disord，2017，43（10）：27-32.

[25] HARA K，ONDA K，OUCHI H，et

al. A case of vascular parkinsonism

associated with hyperhomocysteinemia and

methylenetetrahydrofolate reductase gene variant

（C677T）[J]. Clinical neurology，2016，56（2）：77-

81.

[26] ZOU J，CHEN Z，LIANG C，et al. Trefoil Factor

3, Cholinesterase and Homocysteine: Potential

Predictors for Parkinson's Disease Dementia and

Vascular Parkinsonism Dementia in Advanced

Stage[J]. Aging Dis，2018，9（1）：51-65.

[27] 魏岗之. 血管性帕金森综合征临床病理报告[J]. 中华

神经科杂志，2004，43（7）：473-474.

[28] VALE T C，CARAMELLI P，CARDOSO F.

Clinicoradiological comparison between vascular

parkinsonism and Parkinson’s disease［J]. J Neurol

Neurosurg Psychiatry，2014，86（5）：547-553.

[29] 齐江彤，查曹兵，陈伟良，等. 血管性帕金森综合征

与帕金森病的临床特点与影像学特征比较[J]. 武警

医学，2015，26（6）：545-547.

[30] PERALTA C，WERNER P，HOLL B，et al.

Parkinsonism following striatal infarcts：incidence

in a prospective stroke unit cohort[J]. J Neutral

Transm，2004，111（10-11）：1473-1483.

[31] 翁穗青，王刚，刘建荣. 血管性帕金森综合征及原发

性帕金森病的临床特点及磁共振成像上脑白质病

变严重程度的比较[J]. 内科理论与实践，2010，5（5）：

422-424.

[32] CHEN Y F，TSENG Y L，LAN M Y，et al. The

relationship of leukoaraiosis and the clinical severity

of vascular Parkinsonism[J]. J Neurolo Sci，2014，

346（1-2）：255-259.

[33] STASZEWSKI J，PIUSI?SKAMACOCH R，

BRODACKI B，et al. Vascular parkinsonism and

vascular dementia are associated with an increased

risk of vascular events or death[J/OL]. Arch Med Sci

Atheroscler Dis，2017，2（1）：e16-e23. https：//doi.

org/10.5114/amsad.2017.68549.

[34] 代昌飞，张绒. 影响脑卒中患者并发血管性帕金森

综合征的高危因素分析[J]. 西南国防医药，2016，26

（2）：137-139.