Abstract:

Objective To evaluate the effect of butylphthalide on executive function in patients with mild vascular cognitive impairment (MVCI). Methods A total of 48 MVCI patients were included in this study, all of whom were divided into observation group (n =24) and control group (n =24). On the base of conventional therapy, Butylphthalide (200 mg, tid) was added to the observation group, and Vitamin E (100 mg, tid) was added to control group, with a treatment course of 90 days in each group. Executive function of patients were evaluated by the following tests: trail making test A and B (TMT-A and B), digit span test (including forward and backward), verbal fluency test (VFT) and clock drawing task. Executive function changes of two groups before and after treatment between the two groups were compared to evaluate the effect of butylphthalide on executive function in MVCI patients. Results The baseline cognition and executive function of two groups had no statistical difference. After treatment, the TMT-A [(53.65±0.88) vs (56.22±0.87)] and TMT-B [(174.95±1.99) vs (177.41±1.44)] scores in observation group were significantly lower than that in control group, the digit span forward and backward score [(5.05±1.22) vs (4.59±0.33)] and the VFT score [(13.29±0.88) vs (12.43±1.02)] in observation group were significantly higher than that in control group. There was no statistical difference in CDT between the two groups. Conclusions Butylphthalide can improve the executive function of patients with MVCI.

Key words: Mild vascular cognitive impairment; Butylphthalide; Executive function

摘要：

目的 评估口服丁苯酞对血管性轻度认知障碍患者执行能力的影响。 方法 选择轻度血管性认知功能障碍患者48例，分为观察组24例，对照组24例。观察组服用丁苯 酞200 mg，每日3次，对照组服用维生素E 100 mg，每日3次，共90 d。比较两组治疗前及治疗后连线A 和连线B测试、数字广度顺背倒背、言语流畅性测验（verbal fluency test，VFT）、画钟测验量表评分， 评价丁苯酞对患者执行功能的影响。 结果 治疗前，两组认知和执行功能差异无统计学意义。治疗后，观察组连线A（[ 53.65±0.88）vs （56.22±0.87）]和连线B（[ 174.95±1.99）vs（177.41±1.44）]测试评分低于对照组，差异有统计学意义； 数字广度顺背倒背测试（[ 5.05±1.22）vs（4.59±0.33）]和VFT（[ 13.29±0.88）vs（12.43±1.02）]评分 高于对照组，差异有统计学意义；两组画钟测试差异无统计学意义。 结论 丁苯酞可以改善轻度血管性认知障碍患者执行功能。

关键词: 轻度血管性认知障碍; 丁苯酞; 执行功能