Abstract: Objective  To investigate the relationship between the triglyceride-glucose (TyG) index and moyamoya disease (MMD) as well as its clinical manifestations.
Methods  Patients with MMD who were hospitalized in the Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, and healthy controls during the same period were retrospectively and consecutively enrolled between August 2022 and May 2024. Propensity score matching for sex and age was performed, and the matched MMD patients were assigned to the MMD group, while the healthy controls were assigned to the control group. Demographic data, laboratory test results, and imaging data were collected for the MMD patients, and the TyG index was calculated. Logistic regression analysis was performed to explore the relationship between the TyG index and Suzuki stages as well as clinical manifestations of MMD. 
Results  A total of 205 patients with MMD and 231 healthy controls were enrolled. After propensity score matching, 187 patients in the MMD group and 187 healthy controls were finally matched. The TyG index was higher in the MMD group compared to the control group [8.54 (8.12-8.95) vs. 8.05 (7.81-8.42), P<0.001]. There were no significant differences in the TyG index among different Suzuki stages and clinical manifestations within the MMD group. Correlation analysis showed that the TyG index was positively correlated with age in both the MMD group (r=0.31, P<0.001) and the control group (r=0.28, P<0.001). Moreover, within the same age range, the TyG index was higher in the MMD group than in the control group. Logistic regression analysis showed that elevated TyG index was not significantly associated with Suzuki stages or clinical manifestations. 
Conclusions  The TyG index can reflect the glucose and lipid metabolic disturbances associated with insulin resistance in patients with MMD. In the future, it may be used to assess individual metabolic characteristics of MMD, providing a reference for personalized precision interventions.

Key words: Moyamoya disease; Stroke; Triglyceride-glucose index

摘要： 目的 探讨甘油三酯-葡萄糖（triglyceride-glucose，TyG）指数与烟雾病及其临床表现的关系。
方法 回顾性连续纳入2022年8月—2024年5月于首都医科大学附属北京天坛医院神经外科住院治疗的烟雾病患者及同时期健康对照者，并对其进行性别和年龄倾向性评分匹配，将匹配后的烟雾病患者纳入烟雾病组，健康对照者纳入对照组。收集烟雾病患者入院时人口学资料、实验室检查结果及影像学检查资料，并计算TyG指数。采用logistic回归分析，探讨TyG指数与烟雾病Suzuki分期及临床表现的关系。 
结果 共纳入205例烟雾病患者及231例健康对照者，经倾向性评分匹配后，最终匹配到烟雾病组与对照组各187例。烟雾病组TyG指数高于对照组[8.54（8.12～8.95）vs. 8.05（7.81～8.42），P<0.001]。烟雾病组内不同Suzuki分期及临床表现之间的TyG指数差异不具有统计学意义。相关性分析显示，烟雾病组（r=0.31，P<0.001）与对照组（r=0.28，P<0.001）的TyG指数均与年龄增加呈正相关，且在相同年龄段中，烟雾病组的TyG指数高于对照组。logistic回归分析提示，TyG指数升高与Suzuki分期及临床表现无显著关联。
结论 TyG指数可反映烟雾病患者胰岛素抵抗相关的糖脂代谢紊乱状态，未来或可用于评估烟雾病的个体代谢特征，为疾病的个体化精准干预提供参考。

关键词: 烟雾病; 卒中; 甘油三酯-葡萄糖指数