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Table of Content

    20 February 2020, Volume 15 Issue 02
    Give Full Attention to the Role of General Practitioners, Build Tridimensional Stroke Prevention and Control System
    MA Li, ZHANG Ya-Qing, WANG Chen
    2020, 15(02):  115-118.  DOI: 10.3969/j.issn.1673-5765.2020.02.001
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    Prospect for Research on Translational Medicine
    FAN Li-Zhen, XU Yun
    2020, 15(02):  119-125.  DOI: 10.3969/j.issn.1673-5765.2020.02.002
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    Comparison of Application Value of Three Stroke Screening Scales in Rapid Referral of Suspected Stroke Patients in Community
    SUN Bei-Bei, YAO Bo, FANG Cai, WANG Yun-Xuan, LI Mei-Xiang, MA Li
    2020, 15(02):  126-129.  DOI: 10.3969/j.issn.1673-5765.2020.02.003
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    Objective To investigate the application value of three stroke screening scales FAST, recognition of stroke in the emergency room (ROSIER) and Los Angeles prehospital stroke screen (LAPSS) in rapid referral of suspected stroke patients in the community. Methods The suspected stroke patients who were initially treated in Dongxiaokou Community Health Service Center of Changping District and Yongning Community Health Service Center of Yanqing District in Beijing from January 2018 to September 2019 were screened by FAST, ROSIER and LAPSS scales, respectively. According to the final diagnosis of patients in superior hospitals, they were divided into stroke group and non-stroke group. The accuracy, sensitivity and specificity of the three evaluation scales were compared. Results A total of 309 patients were enrolled, with an average age of 70.5±11.6 years and 156 males (50.5%). There were 243 cases (78.6%) in stroke group and 66 cases (21.4%) in non-stroke group. The accuracy of FAST, ROSIER and LAPSS in stroke screening was 92.2%, 71.5% and 67.3% (P <0.001),respectively. The sensitivity is 94.2%, 66.3% and 60.5% (P <0.001), respectively. The specificity was 84.8%, 90.9%, and 92.4% (P =0.327), respectively. Further pairwise comparison showed that the accuracy and sensitivity of FAST were better than that of ROSIER and LAPSS (all P <0.001). Conclusions FAST scale has a good application value, and it is suitable to be a tool for rapid referral of newly diagnosed suspected stroke patients in the community.

    Analysis on Influence Factors of the Willingness of Community Residents to Sign up for Family Doctor Service in Songshan New District of Jinzhou City
    LI Ke, LU Cheng-Quan, WANG Jian, WANG Shuang
    2020, 15(02):  130-134.  DOI: 10.3969/j.issn.1673-5765.2020.02.004
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    Objective To investigate the influencing factors of the community residents' willingness to sign up for a family doctor service by implementing a family doctor service contract project in Songshan New District of Jinzhou City. Methods The convenience sampling method was used in this study, a questionnaire survey was conducted on the willingness of signing up for family doctors service among the residents of 11 communities in Lingnan Street, Songshan New District, Jinzhou City from March to June 2017. The content of this survey included the residents’ general situation, health status, the level of understanding this service and the related publicity. Multivariate logistic regression analysis was used to explore the factors affecting the residents’ willingness to sign a contract. Results A total of 2500 questionnaires were sent out in this survey, 2266 valid questionnaires were collected, and the effective response rate was 90.6%. 71.8% (1626/2266) residents were willing to sign the contract. The multivariate analysis results showed that the higher age (OR 2.026, 95%CI 1.561-2.631, P <0.001) and education (OR 1.180, 95%CI 1.062-1.311, P =0.002) and understanding level (OR 1.211, 95%CI 1.065-1.377, P =0.004), as well as the residents who worked in administrative institutions (OR 1.323, 95%CI 1.002-1.576, P =0.047), and received this service publicity (OR 3.026, 95%CI 2.355-4.364, P <0.001), were more willing to sign up for family doctor service.

    Conclusions The overall level of the community residents’ willingness to sign up for a family doctor service was higher. The residents who were elder, had higher education and more understanding, worked in administrative institutions and received this service publicity were more willing to sign family doctor service contract.

    Efficacy and Safety of SWIM Technique for Acute Ischemic Stroke Due to Large Vessel Occlusion in Posterior Circulation
    WANG Ya-Jun, FAN Tie-Ping, LI Di
    2020, 15(02):  135-140.  DOI: 10.3969/j.issn.1673-5765.2020.02.005
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    Objective To observe the efficacy and safety of SWIM technique in the treatment of acute ischemic stroke due to posterior circulation large vessel occlusion. Methods A retrospective analysis of clinical data of patients with posterior circulation acute ischemic stroke treated with SWIM technique in the Dalian Central Hospital from February 2017 to November 2018 was undertaken. The outcomes were reperfusion immediately after surgery (successful reperfusion was defined as mTICI ≥2b), mRS score at 90 days (good prognosis was defined as mRS score ≤2), and any intracranial hemorrhage within 24 hours after surgery and allcause death at 90 days. Results A total of 35 patients were included, with an average age of 66.1±12.1 years, and 26 males (74.3%), the median baseline NIHSS score was 22 (15-34). The rate of successful recanalization was 94.3% (33/35), the rate of good prognosis at 90 days was 45.7% (16/35), the rate of intracranial hemorrhage within 24 hours was 17.1% (6/35), and the all-cause mortality at 90 days was 37.1% (13/35). Univariate analysis showed that the lower NIHSS score at admission (P =0.001), a higher pc-ASPECTS score at admission (P =0.016), a shorter time from onset to door (P =0.039), a shorter time from onset to recanalization (P =0.047), a better reperfusion (P =0.036), and a lower percentage of drinking (P =0.042) were associated with good prognosis. Conclusions SWIM technique is relatively safe and effective for patients with posterior circulation acute ischemic stroke.

    Relationship between Monocyte-to-HDL Cholesterol Ratio and Short-term Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis
    LIU Hong-Bing, LIU Kai, PEI Lu-Lu, GAO Yuan, ZHAO Lu, FANG Hui, SONG Bo, XU Yu-Ming
    2020, 15(02):  141-145.  DOI: 10.3969/j.issn.1673-5765.2020.02.006
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    Objective To investigate the relationship between monocyte-to-HDL cholesterol ratio (MHR) and short-term prognosis in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis. Methods A retrospective analysis of consecutive AIS patients treated with intravenous thrombolysis in Department of Neurology of the First Affiliated Hospital of Zhengzhou University from January 2015 to December 2017 was undertaken. Functional outcome at 90 days was evaluated by the mRS. Good outcome was defined as a mRS score of 0-2. Multivariate logistic regression analysis was conducted to evaluate the relationship between MHR and 90-day outcome. The ROC curve analysis was performed to evaluate the predictive value. Results A total of 281 patients were included, with an average age of 59.54±12.49 years and 183 males (65.1%). 223 cases (79.4%) had good prognosis. Multivariate analysis showed that higher age (OR 1.03, 95%CI 1.01-1.06, P=0.013), baseline NIHSS score (OR 1.31, 95%CI 1.17-1.44, P<0.001) and MHR (OR 2.39, 95%CI 1.10-5.25, P=0.028) were independent predictors for 90-day poor prognosis. Subgroup analysis showed that high MHR (OR 5.15, 95%CI 1.28-20.77, P=0.021) was an independent predictor for 90-day poor prognosis in patients with large atherosclerotic stroke. ROC curve analysis showed that the optimal cut-off point of MHR was 0.48, and the sensitivity and specificity of predicting short-term poor prognosis were 79.41% and 58.33%. Conclusions MHR was an independent predictor for short-term prognosis after venous thrombolysis in AIS patients, especially in patients with large atherosclerotic stroke.

    Community Family Doctor Service Contract Model:A Case of Mild Stroke Pre-hospital Recognition and Rehabilitation Management
    MAO Xiu-Ying, WANG Jia-Ming, YANG Hua
    2020, 15(02):  148-151.  DOI: 10.3969/j.issn.1673-5765.2020.02.007
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    A case of Cerebral Hemorrhage Treated with Community-based Time Management Rehabilitation for Limb Function Recovery
    ZHAO Ying, ZHU Xiao-Liang, CHEN Hai-Ying
    2020, 15(02):  152-154.  DOI: 10.3969/j.issn.1673-5765.2020.02.008
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    A Case of Community Rehabilitation for Hemiplegic Shoulder Pain Poststroke
    LUO Feng, LI Yi-Lu, ZHOU Zhe
    2020, 15(02):  155-157.  DOI: 10.3969/j.issn.1673-5765.2020.02.009
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    Experts Consensus on Research on Prevention and Treatment of Poststroke Cognitive Impairment in China Chinese Stroke Association
    Cognitive Impairment Research Roundtable Experts Group
    2020, 15(02):  158-166.  DOI: 10.3969/j.issn.1673-5765.2020.02.010
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    Lancet N: A Breakthrough on Long-term Dual Antiplatelet Therapy for Stroke Secondary Prevention
    YANG Zhong-Hua
    2020, 15(02):  167-168.  DOI: 10.3969/j.issn.1673-5765.2020.02.011
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    JAMA N: A Blood Pressure Target Less than 130/80 mm Hg in Stroke Secondary Prevention?
    YANG Zhong-Hua
    2020, 15(02):  169-170.  DOI: 10.3969/j.issn.1673-5765.2020.02.012
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    Obesity for Stroke: Beneficial and Harmful
    John H.Zhang
    2020, 15(02):  171-178.  DOI: 10.3969/j.issn.1673-5765.2020.02.013
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    A Case of Acute Cerebral Infarction with Hemorrhagic Transformation and Floating Thrombus in Culprit Artery after Thrombectomy
    XIAO Li-Po, ZHAO Ting-Yu, JI Xun-Ming, DUAN Jian-Gang
    2020, 15(02):  179-183.  DOI: 10.3969/j.issn.1673-5765.2020.02.014
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    The Third China National Stroke Registry (CNSR-Ⅲ) for Patients with Acute Ischaemic Stroke or Transient Ischaemic Attack
    JING Jing
    2020, 15(02):  184-185.  DOI: 10.3969/j.issn.1673-5765.2020.02.015
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    Whether to Restart Antiplatelet Therapy after Intracerebral Haemorrhage in Patients Who Were on Antithrombotic Therapy: RESTART Study
    DING Ya-Rong, LIU Li-Ping, WANG Yong-Jun
    2020, 15(02):  186-189.  DOI: 10.3969/j.issn. 1673-5765.2020.02.016
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    Advances in the Association between Atherosclerotic Plaques in Multiple Vascular Bed and Cerebrovascular Events
    LI Dong-Ye, ZHAO Xi-Hai, SHEN Jun
    2020, 15(02):  190-194.  DOI: 10.3969/j.issn.1673-5765.2020.02.017
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    The pathological characteristics and risk factors of atherosclerotic plaques in cerebral arteries, coronary arteries and peripheral arteries were different. The atherosclerotic plaque in single vascular bed or multiple vascular beds has a certain predictive value for cerebrovascular events. This article reviewed the pathogenesis, disease characteristics and related risks of atherosclerosis in different vascular beds, to provide reference for the etiological diagnosis, treatment and prevention of atherosclerotic stroke.

    Progress of Ring Finger Protein 213 Gene-related Cerebrovascular Disease
    ZHOU Hong-Yu, SUO Yue, CHEN Wei-Qi, WANG Yong-Jun
    2020, 15(02):  195-201.  DOI: 10.3969/j.issn.1673-5765.2020.02.018
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    Intracranial major arterial stenosis / occlusion ( ICASO) is one of the most common causes of ischemic stroke in China. Previous studies have suggested that ICASO is similar to moyamoya disease in involved blood vessels and ethnic differences. The ring finger protein 213 (RNF213) gene is known to be the first reported susceptibility gene to moyamoya disease. Recently, several teams have reported that RNF213 gene is also associated with ICASO, atherosclerotic ischemic stroke and intracranial aneurysms, which suggests that RNF213 gene may be closely related to the occurrence and development of cerebrovascular diseases. So this paper summarized the structure, function, gene polymorphism of RNF213 and its correlation with cerebrovascular diseases by reviewing the relevant literature at home and abroad.

    Antiplatelet Therapy in Endovascular Treatment for Ischemic Cerebrovascular Disease
    MA Gao-Ting, MIAO Zhong-Rong
    2020, 15(02):  202-208.  DOI: 10.3969/j.issn.1673-5765.2020.02.019
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    Endovascular treatment (EVT) can significantly reduce the morbidity, mortality and recurrence of ischemic cerebrovascular disease. With the development of EVT technology, materials, and patients screening strategy, EVT is increasely used in patients with ischemic stroke. As an important prevention and treatment regimen of ischemic stroke, antiplatelet therapy is an important part of EVT. Aspirin and clopidogrel are cornerstone antiplatelet agents, however, the specific antiplatelet regimen has not yet been unified. This article reviewed the recommendations of several guidelines for antiplatelet strategies for EVT patients, as well as the antiplatelet regimen in important EVT studies, to provide reference for neuointerventionists.

    Progress in the Relationship between Vitamin D Deficiency and Cardio-cerebrovascular Diseases
    2020, 15(02):  209-214.  DOI: 10.3969/j.issn.1673-5765.2020.02.020
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    Vitamin D is a steroid hormone, it can affect cardiomyocytes, endothelial cells, vascular smooth muscle cells and inflammatory cells by binding to the vitamin D receptors, and then can play the following roles: inhibit cardiac hypertrophy, protect vascular endothelium, regulate inflammatory reaction, which will reduce the risk of cardio-cerebrovascular diseases and improve the patients’ prognosis. Vitamin D deficiency may increase the risk of death in stroke patients. However, the relationship between vitamin D supplements and the prognosis of patients with cerebrovascular disease is still uncertain. This paper reviewed the research progress of the relationship between vitamin D deficiency and cardio-cerebrovascular diseases.

    The Role of Journal Club in Postgraduate Training in Severe Cerebrovascular Disease
    ZHANG Lin-Lin, YANG Yan-Lin, GAO Hao-Ran, CHENG Kun-Ming, ZHANG Pei-Rong, ZHOU Jian-Xin
    2020, 15(02):  215-217.  DOI: 10.3969/j.issn.1673-5765.2020.02.021
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    Objective To observe the role of the journal club in postgraduate training in severe cerebrovascular disease. Methods The postgraduate students majoring in neuro-critical care medicine in Capital Medical University and Weifang Medical College were enrolled. Using the literature on severe cerebrovascular disease, the literature reading report teaching method and the journal club teaching method were successively used to improve the quality and ability of scientific research. After the teaching process, a questionnaire survey was used to compare the ability of medical postgraduates in learning literature on severe cerebrovascular disease under different teaching methods. Results A total of 14 graduate students were enrolled, including 11 males and 3 females. Compared with the literature reading report teaching method, the following aspects were all significantly improved using the journal club teaching method: the reading volume of literature (10.64±0.40 articles/month vs 4.63±0.39 articles/month, P <0.001), the ability of reading professional English (86.54±4.60 points vs 76.91±4.49 points, P <0.001), literature induction ability (76.43±3.52 points vs 66.43±3.66 points, P <0.001), oral English expression ability (82.04±3.62 points vs 71.21±2.55 points, P <0.001) and the teaching satisfaction (89.77±2.36 points vs 79.19±2.12 points, P <0.001). Conclusions For medical postgraduate training in severe cerebrovascular disease, the journal club teaching method is an effective method to promote the students’ quality and ability of scientific research.

    Construction of a Comprehensive and Systematic Management Platform for Senior Talents in Vascular Neurology
    XU Meng-Jia
    2020, 15(02):  218-221.  DOI: 10.3969/j.issn.1673-5765.2020.02.022
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    Objective To improve the quality and benefit of talents management by an informational and systematic management of senior talents in vascular neurology. Methods A comprehensive, systematic and standardized management of senior talents in vascular neurology of Beijing Tian Tan Hospital, Capital Medical University was carried out by applying PDCA (Plan, Do, Check and Action) cycle and establishing a talents management network platform, which can provide data share and the basis for information accumulation and analysis. Results On the basis of quality management, talents management process gets more standardized and rational, and diversified talent cultivation scheme was established. The establishment of senior talents management network platform realized dynamic information management. Conclusions The comprehensive and high-quality management mode of senior talents in vascular neurology realized the modern, scientific and sustainable senior talents management in the hospital.