关键词: 扩大的血管周围间隙; 脑梗死; 自发性出血转化

Abstract:

Objective To analyze the influence of enlarged perivascular spaces (EPVS) on spontaneous hemorrhagic transformation (HT) of cerebral infarction. Methods The clinical data of 412 patients with acute ischemic stroke who were treated in Nanhai Hospital of Southern Medical University during Dec. 2014 to Dec. 2016 were collected. Based on the magnetic resonance imagine (MRI) results, the patients were divided into two groups: with EPVS groups and without EPVS groups. Baseline characteristics, the occurrence of HT were compared. Single factor and multi-factors analysis were made to show the factors that were significantly associated with EPVS. Then, the patients were divided into two groups: with HT groups and without HT groups. Single factor and multi-factors logistic regression analysis were made to study on EPVS and various kinds of risk factors as well as the influence demographic characteristics on HT in patients with ischemic stroke. Results The baseline data comparison showed, compared to patients without EPVS, patients with EPVS were older, more likely with the history of stroke, more likely with leukoaraiosis and more likely with HT. Single factor analysis showed that there were significant difference in age, stroke recurrence, leukoaraiosis and HT. Multi-factors logistic regression analysis showed that HT andleukoaraiosis were significantly associated with EPVS. The analysis of HT showed that there were significant difference in arterial fibrillation, uses of anticoagulant drug, EPVS, large size of infraction, uric acid level and activated partial thromboplastin time (APTT), and EPVS, size of infraction and APTT level were risk factors for HT. Conclusion EPVS was associated with leukoaraiosis and HT, and EPVS was an independent risk factor for spontaneous hemorrhagic transformation in patients with acute cerebral infraction.

Key words: Enlarged perivascular spaces; Stroke; Hemorrhagic transformation