中国卒中杂志 ›› 2019, Vol. 14 ›› Issue (11): 1135-1139.DOI: 10.3969/j.issn.1673-5765.2019.11.011

• 专题综述 • 上一篇    下一篇

脑小血管病与颅内大动脉病变关系的研究进展

杨营营,王拥军,王伊龙   

  1. 100070 北京首都医科大学附属北京天坛医院神经内科;国家神经系统疾病临床医学研究中心
  • 收稿日期:2019-05-19 出版日期:2019-11-20 发布日期:2019-11-20
  • 通讯作者: 王伊龙 yilong528@gmail.com
  • 基金资助:

    国家自然科学基金委员会杰出青年科学基金项目(81825007)
    北京高校卓越青年科学家计划项目(BJJWZYJH01201910025030)
    科技部“十三五”国家重点研发计划“症状性颅内外大动脉狭窄复发进展预测模型与干预策略研究”(2017YFC1307900)
    北京市科学技术委员会“动脉粥样硬化性颅内动脉狭窄的他汀药物治疗研究”(D171100003017001)
    北京市优秀人才培养资助青年拔尖团队(2016000021223TD03)

Advance in Relationship between Cerebral Small Vessel Disease and Intracranial Large Artery Disease

  • Received:2019-05-19 Online:2019-11-20 Published:2019-11-20

摘要:

脑大、小血管在结构和功能上密切相关。越来越多的证据表明脑小血管病常与颅内大动 脉病变共存,严重程度具有一定相关性。颅内大动脉粥样硬化、颅内动脉延长扩张和颅内动脉僵硬 度增加分别反映了颅内大血管的结构和功能改变。本文就脑小血管病与不同颅内大动脉病理变化之 间共存及互相影响的研究现状进行综述,以探讨脑大、小血管病的关系。

文章导读: 本文阐述脑小血管病与颅内大动脉病变的相关性,旨在为揭示脑小血管病的发病机制和个体化干预脑血管疾病提供更多的参考。

关键词: 脑小血管病; 脑白质高信号; 颅内大动脉粥样硬化; 颅内动脉延长扩张; 动脉僵硬度

Abstract:

Cerebral small vessels and large arteries are closely related in structure and function. There is increasing evidence that cerebral small vessel disease often coexists with intracranial large artery disease, and their severity is consistent. Intracranial large artery atherosclerosis, intracranial arterial dolichoectasia and increased arterial stiffness all reflect structural and functional changes of large artery. This article reviewed the research status on the interaction and coexistence between cerebral small vessel disease and intracranial large artery disease.

Key words: Cerebral small vessel disease; White matter hyperintensity; Intracranial large artery atherosclerosis; Intracranial arterial dolichoectasia; Arterial stiffness