骨形态发生蛋白-7对脑梗死神经保护作用的研究进展

doi:10.3969/j.issn.1673-5765.2019.11.022

摘要/Abstract

摘要：

脑梗死是常见的脑血管疾病之一，具有高致死、致残率。近年来有研究表明，在大脑发生缺血缺氧时，骨形态发生蛋白（bone morphogenetic protein，BMP）-7表达上调，参与脑梗死后的病理生理机制。动物实验研究显示，BMP-7既可促进运动神经元恢复、增加神经元缺血耐受性，又可通过抑制细胞凋亡、减弱氧化应激，从而保护缺血脑组织，减少脑梗死体积。基础研究的结果为脑梗死的治疗提供了新的研究思路。

文章导读： 脑梗死时，骨形态发生蛋白-7可通过多种机制促进神经功能恢复，同时，通过多种信号通路保护受损的脑组织。

关键词: 脑梗死; 骨形态发生蛋白-7; 星型胶质细胞; 细胞凋亡; 氧化应激

Abstract:

Cerebral infarction is one of the common cerebrovascular diseases with high mortality and disability rate. Therefore, it is of great significance to study the development and treatment of cerebral infarction. The intervention measures in acute phase of cerebral infarction can directly affect the patient's prognosis. Studies have showed that the expression of bone morphogenetic protein (BMP)-7 was up-regulated in the case of cerebral ischemia and hypoxia. The role of BMP- 7 in cerebral infarction was very complex. In animal experiment, BMP-7 can not only promote motor neurons recovery and increase neuronal ischemic tolerance, but also inhibit apoptosis and weaken oxidative stress, so it plays an important role in protecting ischemic brain tissue and reducing infarction volume, which can provide a new direction for the treatment of cerebral infarction.

Key words: Cerebral infarction; Bone morphogenetic protein-7; Star glial cell; Apoptosis; Oxidative stress

康凯, 佡剑非. 骨形态发生蛋白-7对脑梗死神经保护作用的研究进展[J]. 中国卒中杂志, 2019, 14(11): 1190-1193.

KANG Kai, NAO Jian-Fei. Advances in the Protective Effects of BMP-7 on Neurons in Cerebral Infarction[J]. Chinese Journal of Stroke, 2019, 14(11): 1190-1193.

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