关键词: 吞咽障碍; 卒中; 分子生物学; 研究进展

Abstract: Post-stroke dysphagia is a common complication after stroke, which refers to the difficulty in swallowing due to stroke. The molecular mechanism of post-stroke dysphagia occurrence and development has not been clarified. The nucleus tractus solitarius and nucleus ambiguus, the two key regions of regulating swallowing function, can secrete a variety of neurotransmitters which are closely related to swallowing function. The neurotransmitters such as 5-HT and 5-HT1A receptors, glutamate (Glu) and NDMA receptors in nucleus tractus solitarius, and calcitonin gene-related peptide (CGRP) and SOM, NOS neurons, glutamate, GABA in the nucleus ambiguous, all play an important role in the initiation, control and related activities of swallowing. Combined with the latest achievements in the field of molecular biology, the possible pathogenesis of post-stroke dysphagia were elaborated in this article.

Key words: Dysphagia; Stroke; Molecular biology; Progress