TET2突变相关不确定潜能的克隆性造血与卒中发生发展的研究进展

doi:10.3969/j.issn.1673-5765.2022.04.016

摘要/Abstract

摘要： 与年龄相关的不确定潜能的克隆性造血（clonal hematopoiesis of indeterminate potential， CHIP）能通过激活炎症促进动脉粥样硬化的发生、发展，从而增加心脑血管疾病风险。作为最常见的CHIP相关突变的表观遗传调控基因之一，甲基胞嘧啶双加氧酶2（ten-eleven translocation-2，TET2）基因突变可通过组蛋白去乙酰化作用增加巨噬细胞中IL-1β等促炎因子的转录，加速动脉粥样硬化斑块的形成，并与卒中风险增加及预后不良有关。未来通过靶向TET2基因及其相关机制通路可能有助于发现降低卒中风险或改善卒中预后的新途径。

文章导读： TET2基因突变相关CHIP可能通过炎症通路增加卒中风险，可能成为未来预防和治疗卒中的靶点。

关键词: 甲基胞嘧啶双加氧酶2基因; 卒中; 不确定潜能的克隆性造血; 动脉粥样硬化; 炎症

Abstract: Age-related clonal hematopoiesis of indeterminate potential (CHIP) promotes the development of atherosclerosis by activating inflammation, which increases the risk of cardiovascular diseases. As one of the most common epigenetic regulatory genes among CHIP, the mutations in the ten-eleven translocation-2 (TET2) gene can increase the transcription of inflammatory factors such as IL-1β in macrophages through histone deacetylation. Therefore, it accelerates the development of atherosclerotic plaque, and is related with increasing risk of stroke and poor prognosis. In the future, research on targeting TET2 and its related mechanism pathways may help explore new strategies to reduce the occurrence of stroke and improve the patients’ prognosis.

Key words: TET2 gene; Stroke; CHIP; Atherosclerosis; Inflammation

瓮佳旭, 仇鑫, 李子孝. TET2突变相关不确定潜能的克隆性造血与卒中发生发展的研究进展[J]. 中国卒中杂志, 2022, 17(04): 413-417.

WENG Jiaxu, QIU Xin, LI Zixiao. Progress of the Relationship between TET2 Mutation Related Clonal Hematopoiesis of Indeterminate Potential and Stroke[J]. Chinese Journal of Stroke, 2022, 17(04): 413-417.

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