卒中缺血性半暗带功能磁共振成像评估的研究进展

doi:10.3969/j.issn.1673-5765.2022.11.018

摘要/Abstract

摘要： 急性缺血性卒中是导致急性脑组织损伤的重要原因，是中老年人致残、死亡的主要因素，可挽救缺血组织的早期发现是临床及时干预治疗的关键。随着功能磁共振成像技术的发展，临床可从水分子扩散、血流动力学、氧合水平、pH值、代谢及侧支循环等方面全方位评价脑组织的病理改变，为疾病进展及预后评估提供更全面的信息。本文综述急性缺血性卒中缺血性半暗带功能磁共振成像的研究进展，以期为卒中患者的评估和治疗计划提供影像学支撑与指导。

文章导读： 传统的弥散/灌注不匹配作为诊断缺血性半暗带“金标准”地位现遭受冲击，但敏感性及特异性仍较高，故依然广泛使用。新技术各有优势，如DTI及其衍生序列FW-DTI更贴近病理生理的细节，APT可帮助识别半暗带内的细节划分（良性缺血及半暗带）等，需要临床医师和影像科医师个体化选择，做出综合判断。

关键词: 卒中; 缺血性半暗带; 功能磁共振成像; 医学影像技术学

Abstract: Acute ischemic stroke is one of the most important causes of acute brain injury, and early detection of salvaged ischemic brain tissue is the key to timely clinical intervention. With the development of functional magnetic resonance imaging (fMRI), the pathological changes of brain tissue can be comprehensively evaluated from multiple aspects of water molecular diffusion, hemodynamics, oxygenation, pH, metabolism and collateral circulation, which provide more information for evaluating disease progression and prognosis. The article reviewed the progress of fMRI in evaluating ischemic penumbra in acute ischemic stroke, so as to provide imaging evaluation reference for stroke diagnosis and treatment.

Key words: Stroke; Ischemic penumbra; Functional magnetic resonance imaging; Medical imaging

陈扬, 张婧, 陈芬, 丁杏, 陈昆涛. 卒中缺血性半暗带功能磁共振成像评估的研究进展[J]. 中国卒中杂志, 2022, 17(11): 1264-1270.

CHEN Yang, ZHANG Jing, CHEN Fen, DING Xing, CHEN Kuntao. Progress of Functional Magnetic Resonance Imaging in Evaluating Penumbra in Ischemic Stroke [J]. Chinese Journal of Stroke, 2022, 17(11): 1264-1270.

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