关键词: 血管紧张素Ⅱ受体-1; 基因多态性; 脑梗死

Abstract: Objective To explore the relationship between angiotensin II type I receptor (AT1R) A1166C genepolymorphisms and cerebral infarction(CI).Methods The study population was comprised of 77 patients with cerebral infarction and 98healthy individuals. The AT1R-A1166C genotypes were determined by restriction fragment lengthpolymorphism.Results CC genotype was not found both in CI and control group. In CI group, genotypicfrequencies of AA and AC were 38.9% and 61.1%, respectively. The allele frequency of A was 0.695and C was 0.305. In control group, genotypic frequencies of AA and AC were 91.8% and 8.2%,respectively. The allele frequency of A was 0.959 and C was 0.041. AT1R-A1166C polymorphismrevealed significant difference of genotype and allelic distribution between CI patients and controls.In CI group, patients with AC genotype showed significantly higher blood pressure than those withAA genotype. The systolic blood pressure in patients with AA genotype, as well as the systolic anddiastolic blood pressure in patients with AC genotype in CI group were statistically higher thanthose in control group.Conclusion The polymorphism of AT1R-A1166C is related to the incidence of cerebral infarctionand contributes to the development of hypertension, especially for the diastolic blood pressure.

Key words: Angiotensin II type I receptor; Gene polymorphism; Cerebral infarction