›› 2007, Vol. 2 ›› Issue (04): 83-87.

• 综述 • 上一篇    下一篇

缺血性脑损伤与神经干细胞的再生

侯铁军,程焱   

  1. 天津市天津医科大学总医院神经病学研究所
  • 收稿日期:2006-10-23 修回日期:2006-09-23 出版日期:2007-04-20 发布日期:2007-04-20
  • 通讯作者: 侯铁军

Cerebral Ischemic Injury and Regeneration of Neural Stem Cells

HOU Tie-jun, CHENG Yan.   

  • Received:2006-10-23 Revised:2006-09-23 Online:2007-04-20 Published:2007-04-20
  • Contact: HOU Tie-jun

摘要: 脑缺血可在成年哺乳动物脑内诱发神经再生,这可能有潜在的治疗价值。本文阐述了脑缺血后神经干细胞的增殖、迁移、分化和整合情况及血管微生态的重要作用,分析了侧脑室下区、齿状回和其他部位的神经再生情况以及老年脑神经再生的特点。

关键词: 脑缺血; 神经再生; 神经干细胞; 血管微生态

Abstract: Cerebral ischemia can induce neurogenesis in the adult mammalian brain, whichprobably has therapeutic potentialities. In this review we focus on the proliferation, migration,differentiation and integration of neural stem cells following cerebral ischemia, and we also discussthe important role of vascular niche, neurogenesis in the subventricular zone, the dentate gyrus andother brain regions, and neurogenesis in the aged brain.

Key words: Cerebral ischemia; Neurogenesis; Neural stem cells; Vascular niche