关键词: 动脉粥样硬化; 椎动脉; 基底动脉; 狭窄; 成形术; 支架

Abstract: Objective To examine long-term outcome of a largest case series to date after elective stenting of symptomatic atherosclerotic intracranial vertebrobasilar artery(VBA) stenosis.Methods During September 2001 till September 2007, elective stenting with a balloon-expandable stent was performed in 116 consecutive patients with atherosclerotic intracranial vertebrobasilarartery(VBA) stenosis ≥50% that resulted in qualifying stroke or TIA(Transient Ischemic Attack)event within 180 days.Results There were eight strokes within 30 days, and five strokes in the VBA territory after 30 days(mean of 1005 days). The annual stroke rate in the VBA territory (including any stroke and death within 30 days) was 4.0%Significantly higher stroke-free survivals in the vertebrobasilar territorywere found in stent success subgroup and VA stenosis patients.Conclusion Elective stenting can reduce the annual stroke risk and improve function outcome of patients with symptomatic atherosclerotic vertebrobasilar stenosis that compares favorably to medical therapy. The long-term outcome is associated with successful stent placement and stenotic site.

Key words: Atherosclerosis; Vertebral artery; Basilar artery; Stenosis; Angioplasty; Stent