关键词: 尤瑞克林; 脑梗死

Abstract: Objective To investigate the effect of Urinary Kallidinogenase on acute progressive cerebral infarction.Methods 125 patients with acute progressive cerebral infarction were randomly divided into two groups: treatment group with Urinary Kallidinogenase (n=63) and control group (n=62). According to Chinese Guidelines for Prevention and Management Cerebrovascular Disease, two groups were treated with basic therapy, such as antiplatelet, neurologic protection, blood pressure control,nerve recovery and so on. On basis of control group, treatment group was administrated intravenous injection of Urinary Kallidinogenase 0.15PNAU per day for 7~14 days. The primary efficacy was evaluated by NIHSS(the National Institutes of Health stroke scale, NIHSS), ADL(Activities of daily living,ADL) and clinical effective.Results Our study showed that the scores in ADL and NIHSS in the treatment group was higher than those of control group, Urinary Kallidinogenase could significantly reduce neurological deficits and the effective rate was up to 90.48%, curative rate of recent period was 52.38% compared with control group.Conclusion Urinary Kallidinogenase is maybe effective and safe in the treatment of acute progressive cerebral infarction.

Key words: Urinary Kallidinogenase; Brain infarction; acute