关键词: 脑梗死; 超声心描记术; 左心室功能; 脑钠素

Abstract: Objective To observe the changes of left ventricular function in patients with acute cerebral infarction and the relationship between acute cerebral infarction and plasma brain natriuretic peptide(BNP) by using echocardiography and determining plasma BNP concentration. It willpvoide potentile methods for preventing and treating cardiac impairment caused by acute cerebral infarction.Methods Thirty patients within 24 hours after the onset of acute cerebral infarction diagnosed by clinical manifestation and head computed tomography were enrolled. All enrolled patients had no history of heart diseases and no complications such as cardiac insufficiency and arrhythmia. And inthe same period, twenty-one sex and age matched healthy persons were enrolled as control groups.All patients and controls were undergone echocardiographic investigation and plasma determination of BNP concentration.Results (1)The mean of cardiac stroke volume(SV), cardiac output(CO) and cardiac index(CI) in acute cerebral infarction group was much lower than those in control group(38±14 vs 53±12,P <0.01; 3.00±1.39 vs 3.87±1.33, P <0.05; 1.77±0.79 vs 2.37±0.81, P <0.01, respectively). (2)The mean of cardiac left ventricular ejection fraction(LVEF) in acute cerebral infarction group was much lower than those in control group(45±14 vs 68±8, P <0.01). (3)The mean of cardiac peak earlydiastolic velocity E wave/ peak late diastolic velocity A wave (E/A ratio) in acute cerebral infarction group is lower than those in control group(0.97±0.32 vs 1.47±0.23, P <0.01). (4)The plasma BNP concentration in acute cerebral infarction group was higher than that in control group(P <0.01).Conclusion Acute cerebral infarction can induce the decrease of left ventricular systolic and diastolic function. The plasma BNP concentration increases after the onset of acute cerebral infarction, The rise of plasma BNP concentration may be caused mainly by the pathophysiologicmechanism of acute cerebral infarction.

Key words: Brain infarction; Echocardiography; Ventricular function; left; Natriuretic peptide; brain