关键词: 高血糖; 卒中; 缺血性; 预后

Abstract: Objective To investigate the role of hyperglycemia in the prognosis of patients with early stage acute ischemic stroke.Methods 143 consecutive patients with acute ischemic stroke (<72 hours) were involved in this prospective study. All of them had random serum glucose measured at admission, and hyperglycemia was defined as ≥7.2mmol/L.We also evaluated their National Institutes of Health Stroke Scale (NIHSS)when they admitted to hospital. Based on their clinical manifestations and physical examination,ischemic stroke patients were classified according to the TOAST (Trial of Org 10172 in Acute Stroke Treatment) scale.30 days post stroke, by means of Modified Rankin Scales (mRS) scale, we evaluatedthe prognosis of patients with early stage acute ischemic stroke.Results (1) Our data showed that hyperglycemia at admission was present in 85 patients (59.4%).By single variable analysis, age, a prior history of diabetes mellitus, NIHSS were risk factors for acute ischemic stroke patients combined with hyperglycemia (P <0.05). Multivariate stepwiselogistic regression analysis showed that prior history of diabetes mellitus, NIHSS were independent risk factor for acute ischemic stroke patients combined with hyperglycemia (P <0.05).(2) By single variable analysis, the influence of age, infection, hyperglycemia, NIHSS,TOAST on mRS scale werestatistically significant difference (P <0.05). Multivariate stepwise logistic regression analysis showed that hyperglycemia, NIHSS were independent risk factor for poor prognosis (P <0.05).Conclusion Our data indicates the high incidence of hyperglycemia in patients with acute ischemic stroke. Hyperglycemia, which is associated with stroke severity, can be a predictor of more severe stroke at its onset. Hyperglycemia is an independent risk factor for poor prognosis in patients withearly stage acute ischemic stroke.

Key words: Hyperglycemia; Stroke; ischemic; Prognosis