关键词: 干细胞; 脑梗死; 移植

Abstract: There is no existing effective treatment to repair neurological damage caused by ischemic stroke. Recent studies have highlighted a novel stem cell-based therapeutic approach for the treatment of ischemic stroke. A number of experiments in animal stroke models and a small number of clinical trials have demonstrated that mobilized and recruited endogenous or implanted exogenous stem cells improve neurological outcomes after stroke. Increasing evidence suggests that stem cells implanted locally or intravenously, or mobilized systemically, could migrate and home into ischemic region under the effects of stromal cell-derived factor-1/CXC chemokine receptor-4 (SDF-1/CXCR4)and β2-intergrin. The mechanism that the stem cell therapy might improve neurological deficits after stroke remain uncertain. Transplanted stem cells may provide a microenvironment with rich trophic factors for the ischemic penumbra surrounding the infarcted area, enhance angiogenesis and vasculogenesis, promote survival, migration, and differentiation of the endogenous stem/precursor cells after stroke, and differentiate into neurons to replace lost neurons.

Key words: Stem cells; Ischemic infarction; Transplantation