关键词: 卒中; 癫; 晚发性癫发作; 危险因素

Abstract:

Objective To investigate the time distribution and influencing factors of post-stroke seizures in terms of seizure control and prevention purpose. Methods The demographic and clinical features, the seizure type and onset time, the infarct location and the electroencephalographic(EEG) findings of 60 stroke patients with a early seizures and of 62 ones with late seizures were retrospectively analysed and compared. Totally 122 cases diagnosed and admitted into hospital with post-stroke seizures by the largest stroke unit in China were included and followed up for at least a half to 5 years(from 2004-2008) in this study. All subjects were divided into two groups: early seizure group defined as seizures occurring within 14 days after acute stroke and later seizure group as seizures occurring >14 days after stroke. Univariately statistics and final multiple regression model(SPSS 13.0 for Windows) were used to find out its influencing factors respectively. Results Univariately statistics showed that early post-stroke seizures occurred most associatelly with hemorrhagic transformation of ischemic stroke and generalized tonic-clonic type seizures insults, while late post-stroke seizures showed some predisposition as associated with temporal lobe lesions and partial seizure type insults. Final multiple regression model study also indicated that the early one was more related to the predictor as diabetes odds ratio(OR=2.664; 95%CI 1.143-6.210). Conclusion The most significant difference is the time of seizure onset, with a low recurrence rate. Diabetes and hemorrhagic transformation of ischemic stroke, generalized tonic-clonic insults in patients with early compared to those with late onset of stroke. Late seizures are more prone to temporal lesion and tend to recur clinically.

Key words: Stroke; Epilepsy; Risk factors