关键词: 颅内动静脉畸形; 脑出血; 基质金属蛋白酶-9; 组织基质金属蛋白酶抑制剂-1

Abstract:

Objective To research the expression of matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-1(TIMP-1) in blood serum of cerebullar arteriovenous malformations(CAVM) and their relationship with hemorrhagic history. Methods 48 patients suffering from CAVM were studied, including 24 patients with hemorrhagic history(CAVM H group) and 24 patients without hemorrhagic history(CAVM N group). 24 patients suffering from essential epilepsy were enrolled into control group(CG group). We researched the expression of MMP-9,TIMP-1 in blood serum by immunohistochemistry. Results Compared with control samples, CAVM samples show a higher expression in MMP-9 and TIMP-1(P<0.01). There was no significant difference in levels of MMP-9, TIMP-1(P>0.05) between CAVM H Group and CAVM N Group. However, CAVM H Group showed a higher expression in MMP-9/TIMP-1 compared with CAVM N Group(P<0.05). Conclusion There is a close relationship between MMP-9, TIMP-1 and the growth, abnormal extension of vessels in CAVMs. MMP-9 is one of the factors to promote expression of TIMP-1. Perhaps disbalance of MMP-9 and TIMP-1 is an important reason of hemorrhage in CAVMs.

Key words: Intracranial arteriovenous malformations; Cerebral hemorrhage; Matrix metalloproteinases 9; Tissue inhibitor of metalioproteinases 1