关键词: 阿托伐他汀; 脑梗死; 颈动脉狭窄

Abstract: Objective To explore the effects of atorvastatin on carotid atherosclerotic plaque in patientssuffering with cerebral infarction(CI) or transient ischemic attack(TIA).Methods One hundred and twenty patients with CI or TIA were randomly divided into therapygroup and control group. The patients in control groups were given anti-platelet aggregation asroutine treatment, and the patients in therapy group were administered anti-platelet aggregation and20mg atorvastatin every night. In the time before treatment, 1 months and 6 months after treatment,Totalcholesterol(TC), Low density lipoprotein-cholesterol(LDL-C) and hige density lipoproteincholesterol(HDL-C) were detectd, while quality and intima-media thickness(IMT) of carotidatherosclerotic plaque were assessed.Results In therapy group, the levels of TC and LDL-C in therapy group were all obviouslydecreased after 1 month and 6 months(P <0.01), and the IMT of carotid atherosclerotic plaque intherapy group were lessened after 6 months(P <0.01). Compared with control group, proportion oflow and mix reverberation plaque of carotid atherosclerotic in therapy group were all obviouslydecreased after 1 month and 6 months(P <0.01), and proportion of high reverberation plaque ofcarotid atherosclerotic had increased(P <0.01). In therapy group, proportion of high reverberationplaque of carotid atherosclerotic in 6 months were increased than one in 1 months(P <0.01). Incontrol group, the reverberation plaque of carotid atherosclerotic were no significant differencesbetween before and after treatment.Conclusion Atorvastatin can decrease the level of LDL-C and TC, and good for stabilize andinverse carotid atherosclerotic plaque.

Key words: Atorvastatin; Brain infarction; Carotid stenosis