关键词: 脑梗死; 颈动脉狭窄; 尿酸

Abstract: Objective To study the relationship between serum uric acid(SUA) level and carotid stenosis in patients with ischemic stroke.Methods Patients with ischemic stroke were examined with subtraction and diagnosed as with(112) and without carotid stenosis(50). Patients with stenosis were further grouped as slight(45), moderate(39) and severe stenosis(28). There were 62 patients with unilateral and 50 patients with bilateral carotid stenosis.Results The level of SUA was significantly higher in patients with carotid stenosis(343±111μmol/L) than in patients without(287±67μmol/L)(P<0.01). SUA was significantly higher in patients with severe stenosis(408±112μmol/L) than in patients with moderate stenosis(351±100μmol/L)(P=0.025) and mild stenosis(296±99μmol/L)(P<0.01), significantly higher in patients with moderate stenosis than in patients with mild stenosis(P=0.017), significantly higher in patients with bilateral stenosis group(378±128μmol/L) than in unilateral stenosis(314±85μmol/L)(P=0.003). Logistic regression analysis showed that SUA level was not an independent risk factor of carotid stenosis(P=0.239). Spearman rank correlation analysis showed that SUA level and the degree of carotid stenosis was positively correlated(r=0.401, P<0.01).Conclusion SUA level may be an important but not independent risk factor for carotid stenosis. There was a correlation between SUA level and the severity of the carotid stenosis.

Key words: Brain infarction; Carotid stenosis; Uric acid