关键词: 脑缺血; 缺血半暗带; 细胞凋亡; 内源性途径; 外源性途径

Abstract: Animal experiments has revealed that there are much of apoptotic cells inischemic region, especially in penumbra during the first several hours or days after an ischemicevent, which accounts for the parts of the total lesions during the initial stages of ischemia. It iscurrently accepted that cerebral ischemia triggers two general pathways of apoptosis: the intrinsicand extrinsic pathway. This brief review provides a general overview of current knowledges ofapoptotic mechanisms after ischemia.

Key words: Brain ischemia; Ischemic penumbra; Apoptosis; Intrinsic pathway; Extrinsicpathway