关键词: 脑梗死; C反应蛋白; 纤维蛋白原; 危险因素

Abstract: Objective To investigate the risk factors and mechanism of ischemic stroke recurrence.Methods Data of 195 patients with ischemic stroke in our hospital were collected. Including age, smoking, history of hypertension or diabetes, the serum levels of lipid, homocysteic acid, fibrinogen, and high sensitivity C-reactive protein (hsC-RP), ultrasonic of the carotid arteries. We follow up the patients for 2 years. Patients were divided into 2 groups: ischemic stroke recurrence group and non-recurrence group. We analyzed the different of risk factors between these 2 groups.Results One hundred and ninety-five cases were included in the present study, 3 of them died of other system disease, 52 of 192 patients(27.1%)had ischemic stroke recurrence. Single factor analysis showed that age, level of hsC-RP and fibrinogen were higher in the ischemic stroke recurrence group than those in non-recurrence group; History of hypertension or diabetes, and carotid plaque were more frequent in the ischemic stroke recurrence group. Logistic regression analysis showed that: hsC-RP>3mg/L(OR 2.72; 95%CI 1.35~5.46;P=0.005)and Fg>4g/L(OR 2.31; 95%CI 1.16~4.58;P=0.017)were the independent predictors of ischemic stroke recurrence.Conclusion Higher hsC-RP and fibrinogen concentration in acute phase after ischemic stroke are the independent predictors of ischemic stroke recurrence.

Key words: Brain infarction; C-reactive protein; Fibrinogen; Risk factor