关键词: 超声检查; 多普勒; 经颅; 屏气试验; 脑血管反应性

Abstract: Objective To use transcranial doppler (TCD) combined with breathing-holding test for evaluatingmiddle cerebral artery reactivity in healthy smoking men.Methods Forty-six healthy smoking men (group A) and 42 healthy non-smoking men (group B)were enrolled. Before and after breathing, the peak systolic velocity (PSV) of middle cerebralartery was monitored by TCD, meanwhile the pulsatility index (PI) and resistance index (RI)were detected, the difference before and after the breathing-holding test and the change ratebetween two groups were calculated.Results After breathing-holding test, the PSV of the two groups were both increased, the PI andRI were both decreased, there was significant difference between before and after breathingholdingtest, P<0.05; The change rate of PSV in group A was (23±7)%, group B was (37±9)%, andthe change rate between the two groups was statistically significant (P <0.05). The change rate ofPI in group A was (19±5)%, group B was (25±8)%, and the change rate between the two groupswas statistically significant (P <0.05). The change rate of RI in group A was (21±6)%, group Bwas (35±7)%, and the change rate between the two groups was statistically significant (P <0.05).Conclusion The cerebrovascular reactivity of healthy smoking men was lower than healthy nonsmokingmen, smoking can result in diminution of cerebrovascular reactivity. TCD combinedwith breathing-holding test can assess the cerebrovascular reactivity.

Key words: Ultrasonography; Doppler; transcranial; Breathing-holding test; Cerebrovascular reactivity