关键词: 窦血栓形成; 颅内; 预后; 有效性; 结果

Abstract: Objective The purpose of this study was to determine the short-term prognosis of patients withcerebral venous thrombosis (CVT) and to validate a predictive outcome score for CVT.Methods We retrospectively investigated consecutive patients who were diagnosed as having CVTadmitted to one stroke center in this observational study. Demographic data, symptoms and signsfrom onset to diagnosis, imaging methods used, location of the thrombus and therapy were retrievedwith case report form by a neurologist. Patients were followed up on the day before discharged.Primary outcome was independent as assessed by modified Rankin Scale (mRS) score ≤2 at theend of follow-up. Sensitivity, specificity, positive predictive values, negative predictive values,negative likely ratio and positive likely ratio were calculated to validate the previous predictiveoutcome score. Receiver operating characteristic (ROC) curves were used to analyze the accuracy.Results From May 2000 to May 2010, we recruited 168 adult patients with CVT. 165 patientswere evaluated with CVT predict score on 17d (8～45d) from onset. At the end of follow-up, 130patients (78.8%) were independent by mRS ≤2. Using the risk score with a cut-off of ≥3 points,sensitivity, specificity and C statistics were 0.75 (95% confidence interval (CI) 0.67～0.82), 0.38(95%CI 0.22～0.55) and, 0.56 (95%CI 0.45～0.68) respectively. And 0.85 (95%CI 0.78～0.91); 0.35(95%CI 0.19～0.51) and 0.60 (95%CI 0.49～0.71, P =0.074＞0.05) respectively with a cut-off of ≥4 points.Conclusion The prognosis of CVT is relative benign A subgroup (21.2%) of CVT patients is atincreased risk of bad outcome. The CVT risk score showed poor predictive value in our study andneed to be evaluated prospectively.

Key words: Sinus thrombosis; intractracranial; Prognosis; Validity Reproducibility of results