关键词: 脑梗死; 糖耐量异常; 心室功能; 左; 预后

Abstract: Objective To observe the changes of left ventricular diastolic function in patients of acute cerebralinfarction with impaired glucose tolerance and its impact on stroke prognosis.Methods One hundred and six patients with acute cerebral infarction were undergone 75g oralglucose tolerance test (OGTT) at two weeks after infarction. According to the results of OGTT, thepatients were divided into normal glucose tolerance group (NGT, 33), impaired glucose tolerancegroup (IGT, 35) and diabetes mellitus group (DM, 38). Glycosylated hemoglobin, myocardialenzymes, blood lipids, liver function, kidney function and other biochemical parameters were testedon the morning after admission in the fast state. All patients were undergone echocardiographyinvestigation to measure left ventricular ejection fraction, E velocity, A velocity and other indicatorsof cardiac function. Ninety days after stroke, the patients will be followed up using modifiedRankin Scale (mRS).Results (1) The E/A ratio<1 reflects impaired left ventricular diastolic function. The proportionof subjects with an E/A ratio<1 was 63.6%, 85.37% and 84.2% in NGT, IGT and DM groupsdifferently. The E/A ratio<1 in IGT group and DM group were higher than that in NGT group, thedifference were statistically significant (χ2=4.42, P =0.036; χ2=3.95, P =0.047). (2) 90 days afterstroke, the level of mRS was negatively related with E/A ratio (r =-0.452, P =0.000), stroke volume(r =-0.228, P =0.020), left ventricular ejection fraction (r =-0.328, P =0.001), fractional shorting(r =-0.301, P =0.002) and E velocity (r =-0.321, P =0.001).Conclusion Impaired left ventricular diastolic function is closely related with the level of bloodglucose in patients with acute cerebral infarction. In the stage of IGT, it has emerged decreased leftventricular diastolic function and affected nerve function recovery after cerebral infarction.

Key words: Brain infarction; Impaired glucose tolerance; Ventricular function; lef; Prognosis