关键词: 脑梗死; 整合素αVβ3; 血管新生; 脑保护; 血流动力学

Abstract: Integrins are important adhesion molecules on cell surface. In the centralnervous system (CNS), they are involved in development and in the adult in areas as diverse assynaptogenesis and activation of microglia, they can also mediate leukocyte extravasation duringCNS inflammation. Recent studies have revealed that integrin alphaVbeta3 (αVβ3) is associatedwith the angiogenesis in many organs including the brain and the hemodynamic changes afterischemic stroke, especially the protection effect of the ischemic tissue by the selective antagonistsof integrin αVβ3 make it a therapeutic target of ischemic stroke and a new interest of these years.

Key words: Brain infarction; Integrin alphaVbeta3; Angiogenesis; Cerebral protection; Hemodynamics