关键词: 脑梗死; 淋巴毒素α; 多态性; 单核甘酸

Abstract: Objective The aim of the present study was to explore whether genetic polymorphisms oflymphotoxin-alpha (LTA) gene are risk factors for noncardiogenic ischemic stroke in HanChinese population.Methods Three common variants of LTA, rs1800683, rs909253 and rs1041981, were genotypedin a sample including 558 noncardiogenic ischemic stroke cases and 557 normal controls usingTaqman-MGB assay in a case-control study. The association analyses were performed at bothsingle nucleotide polymorphism and haplotype levels. Bonferroni correction was applied formultiple corrections.Results No significant association were found between any of these LTA alleles or genotypeswith risk of noncardiogenic ischemic stroke. When AGA haplotype was chosen as the baseline foradjusting conventional risk factors, the protective effect for haplotype GGC remained significant(AGA versus GGC; OR , 0.381; 95%CI , 0.198 to 0.733; P =0.003).Conclusion The GGC haplotype of LTA maybe a protective factor in pathogenesis ofnoncardiogenic ischemic stroke warrants further confirm in a prospective study.

Key words: Brain infarction; lymphotoxin-alpha; Polymorphism; single nucleotide