›› 2010, Vol. 5 ›› Issue (12): 983-986.

• 论著 • 上一篇    下一篇

依达拉奉早期应用于急性缺血性卒中的临床分析

宋来军,李和永,张才,蔡振利,朱淼,伍丽红,刘娜   

  1. 黑龙江省大庆市大庆油田总医院神经内科
  • 收稿日期:2010-04-22 修回日期:2010-03-22 出版日期:2010-12-20 发布日期:2010-12-20
  • 通讯作者: 宋来军

Clinical Analysis of Applying Edaravone Early in Acute Cerebral Infarction

SONG Lai-Jun, LI He-Yong, ZHANG Cai, et al.   

  • Received:2010-04-22 Revised:2010-03-22 Online:2010-12-20 Published:2010-12-20
  • Contact: SONG Lai-Jun

摘要: 目的 观察依达拉奉治疗急性缺血性卒中的疗效。方法 选择82例发病时间在6~72 h的急性缺血性卒中患者,随机分为治疗组42例,对照组40例。治疗组在基础治疗的基础上加用依达拉奉30mg加入0.9%氯化钠注射液100 ml静脉滴注,每天2次,连用14 d;对照组仅给予基础治疗和0.9%氯化钠注射液100ml 静脉滴注,每天2次,连用14 d。比较两组治疗前后的患者临床神经功能缺损程度评分和临床疗效。结果 治疗前两组临床神经功能缺损评分无明显差异(21.23±5.64分 vs 20.23±5.14分,P >0.05)。治疗14 d后,治疗组评分低于对照组(9.60±2.50 vs 12.10±2.21,P=0.027)。治疗组临床疗效总有效率为92.8%,对照组为72.5%,差异有统计学意义(P=0.016)。结论 依达拉奉治疗急性缺血性卒中有显著疗效。

关键词: 脑梗死; 依达拉奉; 治疗结果

Abstract: Objective To observe the effects of edaravone on acute cerebral infarction(ACI).Methods Eighty-two acute cerebral infarction patients who were admitted to hospital 6-72h afteronset were randomly divided into treatment group and control group by half. The treatment groupwas given intravenous edaravone by drops(30 mg edaravone were added to 100 ml physiologicalsaline), twice a day for 14 days. The control group was given the same treatments exceptedaravone. Conditions of both groups before and after the treatment were evaluated by clinicalneurological deficit scores and were compared with each other.Results Fourteen days after treatment, clinical neurological deficit scores of the treatment groupwere significant lower than that of the control group(P =0.027), 14d after treatment, both obviouseffects and effects rates of the treatment group were significant higher than that of the controlgroup P =0.016).Conclusion Edaravone is effective on ACI without any serious adverse reaction being observed.

Key words: Brain infarction; Edaravone; Treatment outcome