关键词: 缺血性卒中; TOAST; 高血压; 预后

Abstract: Objective To clarify the change in high blood pressure(BP) and its relation with prognosis of acute ischemic stroke with no antihypertensive therapy.Methods Consecutive patients who were hospitalized within 48 hours and were diagnosed as acute ischemic stroke were registered prospectively. All patients were divided into four groups refer to the improved Trial of Org10172 in Acute Stroke Treatment(TOAST) criteria of ischemic stroke type. To study the BP levels during the initial 14 hospital days. Death and dependency were assessed at 3 months. Relationship between BP in different time periods and death/dependency rate of three month was analyzed. Spearman's correlation analysis was used to analyze factors relations to death/independent rate.Results The systolic blood pressure(SBP) and diastolic blood pressure(DBP) course and decrease in mean BP in patients of these four groups have no significant differences. This best BP in patients of these four groups has not significant difference. And the correlation of the average of BP and death/dependency rate of three month was not statistically different. However the risk factors relations to death/independent rate at 3 months after onset were different, SBP decreased within 24 hours of admission were significantly associated with death/dependency rate at 3 months after onset in atherosclerosis type and cardioembolism type.Conclusions BP change in different causes of acute ischemic stroke are almost no statistical different. SBP decreased within 24 hours of admission were significantly associated with death/dependency rate at 3 months after onset in atherosclerosis type and cardioembolism type.

Key words: Ischemic stroke; TOAST; Hypertension; Prognosis