关键词: 硝苯地平; 高血压; 原发性; 老年人; 疗效

Abstract: Objective To explore the clinical effect of Nifedipine controlled release tablets on geriatric patients with mild or moderate essential hypertension.Methods Systolic/diastolic blood pressures, and blood pressures variability were compared before and after treatment by self-control design; the quality of life and depression of geriatric patients were evaluated before and after medication using the Medical Outcomes Study Short Form Health Survey(SF-36) and Geriatric Depression Scale(GDS).Results The total effective rates of the mild and moderate essential hypertension geriatric patients were 84.38% and 77.36%. The systolic and diastolic blood pressure of geriatric patients with mild or moderate essential hypertension after treatment were lower than the systolic and diastolic blood pressure before treatment(P<0.01, P<0.01), and the 24h systolic and diastolic blood pressure variability after treatment were lower than before the treatment(P<0.01, P<0.01). The scores of physical functioning(PF), bodily pain(BP), general health(GH), vitality(VT), role-emotional(RE), mental health(MH) of geriatric patients after 8 weeks treatment were higher than before the treatment(P=0.03, P=0.01, P<0.01, P<0.01, P=0.04, P<0.01, P<0.01, P<0.01, P<0.01, P<0.01, P=0.01, P<0.01). The scores of GDS were lower than before the treatment (P<0.01, P=0.02). Six cases of essential hypertensive patients had adverse reactions in observation period.Conclusions The Nifedipine controlled release tablets on geriatric patients with mild or moderate essential hypertension have a good clinical effect of lowering blood pressure. This study indicatesthe Nifedipine controlled release tablets may have a clinical effect of improving quality of life, and relieving the symptoms of depression.

Key words: Nifedipine; Hypertension; essential; Aged; Efficacy